Pharmacia Ab

Torkek Gren

Birgitta Olsson

Lisbeth Nilvebrant

Anders Ringberg

Martin Wikberg

Jan Strombom

Bengt Hallen

The invention relates to a pharmaceutical formulation containing tolterodine or a tolterodine-related compound, or a pharmacologically acceptable salt thereof, as active ingredient, in which the formulation exhibits a controlled in vitro release of the active ingredient in phosphate buffer at pH 6.8 of not less than about 80% after 18 hours, and after oral administration to a patient is capable of maintaining a substantially constant serum level of the active moiety or moieties for 24 hours. The invention also relates to the use of the pharmaceutical formulation for treating overactive bladder and gastrointestinal disorders.

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Kalamazoo, MI, United States of America

Torkek Gren