Basf as

Pronova Biopharma Norge as

Tore Skjaeret

David Alan Fraser

Anne Kristin Holmeide

Hilde Steineger

Ragnar Hovland

Morten Braendvang

The present disclosure relates to compounds of the general formula (I): wherein R, R, R, R, R, R, and Rmay be chosen from different substituents; n is 0, 1, or 2; and X is a hydroxymethyl or a carboxylic acid or a derivative thereof, such as a carboxylate, such as a carboxylic ester, a glyceride, an anhydride, a phospholipid, a carboxamide, a phospholipid, or a prodrug thereof; or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to metabolic diseases and liver diseases, such as non-alcoholic fatty liver disease and cholestasis diseases.

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Oslo, Norway

Tore Skjaeret