Gambro Lundia Ab

Torbjorn Linden

Olof Jansson

Anders Wieslander

Jens Gustafsson

Husam Mohammed

Ola Carlsson

Petronella Schroeder

Jan P Sternby

Ragnar Tryggvason

The present invention relates to removal of protein bound deleterious substances from an extracorporeal biological fluid by changing the affinity of the substance to the protein. The invention relates to the use of displacer substances for removal of deleterious substances. The present invention also relate to a method of removal, a system, a cleaning fluid comprising the displacer substances for removal of deleterious substances.

Cleaning of biological fluid

The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water, a sodium containing concentrate, and a bicarbonate containing concentrate into a ready-for-use dialysis solution. The dialysis acid precursor composition consists of powder components comprising glucose, at least one dry acid and at least one magnesium salt, and optionally potassium salt, and calcium salt. According to the invention the glucose and the at least one magnesium salt, are present as anhydrous components in the dialysis acid precursor composition.

Dialysis precursor composition product

The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consist of powder components comprising sodium chloride, at least one dry acid and at least one magnesium salt, and optionally potassium salt, calcium salt, and glucose. According to the invention said at least one magnesium salt and said optional glucose, are present as anhydrous components in said dialysis acid precursor composition.

Dialysis precursor composition

A dialysis acid precursor assembly including: a bicarbonate containing concentrate and a dialysis acid concentrate solution including powder components mixed with water. The powder components include (1) a sodium chloride powder, (2) at least one dry acid powder, and (3) a magnesium chloride 4.5-hydrate (MgCl.4.5HO) powder in a quantity such that a concentration of about 7.5-50 mM magnesium ions is provided in the dialysis acid concentrate solution.

A package () is configured to store a powdery material () which is to be mixed with a solvent to form a medical solution, such as a dialysis solution. The package () comprises a filled cavity portion () containing the powdery material (), optionally separated into groups of different composition, and a tab portion () integrally formed with the filled cavity portion () and being swept around the filled cavity portion () so as to define a roll-up package. The tab portion () forms a protective barrier that shields the powdery material (), e.g. by counteracting transport of moisture into and out of the package. The tab portion () may also stabilize the package. The roll-up package is compact, and simple to manufacture and handle.

Packaging of powdery material for preparation of a medical solution

A dialysis acid precursor assembly including: a dry dialysis acid precursor composition including sodium chloride, a dry acid and a magnesium chloride 4.5-hydrate (MgCl2.4.5H2O), a calcium salt and at least one of a potassium salt, calcium salt and an anhydrous glucose, and a moisture-resistant container having a water vapor transmission rate less than 0.2 g/m2/d at 38&#xb0; C./90% RH, wherein the dry dialysis acid precursor composition is sealed in the container.

The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water, a sodium containing concentrate, and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consists of powder components comprising glucose, at least one dry acid and at least one calcium salt, and optionally potassium salt, and magnesium salt. According to the invention said glucose and said at least one calcium salt, are present as anhydrous components in said dialysis acid precursor composition.

A dialysis acid precursor assembly including a dialysis acid precursor composition of dry components including anhydrous glucose, a dry acid, a magnesium chloride 4.5-hydrate (MgCl.4.5HO) and a potassium salt or calcium salt, and a moisture-resistant container with a water vapor transmission rate less than 0.2 g/m/d at 38&#xb0; C./90% RH, wherein the dialysis acid precursor composition is sealed within the container.

The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution. The dialysis acid precursor composition consists of powder components comprising sodium chloride, at least one dry acid and at least one calcium salt, and optionally potassium salt, magnesium salt, and glucose. In an embodiment, the at least one calcium salt and the optional glucose are present as anhydrous components in the dialysis acid precursor composition.

The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consists of powder components comprising sodium chloride, at least one dry acid and at least one calcium salt, and optionally potassium salt, magnesium salt, and glucose. According to the invention said at least one calcium salt and said optional glucose, are present as anhydrous components in said dialysis acid precursor composition.

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Hasslo, Sweden

Torbjorn Linden