Novo Nordisk A/s

Novozymes A/s

Novo Nordisk Biotech, Inc.

Novozymes Biotech, Inc

Novo Nordisk-a/s Novo Alle

Novozyme A/s

M & E Biotech A/s

Novo Nordisk of Biotech, Inc.

Torben Halkier

Markus Sakari Kauppinen

Shamkant Anant Patkar

Claus Crone Fuglsang

Grethe Norskov Rasmussen

Kim Borch

Randy M Berka

Stephan Christgau

Henrik Dalbo Slashedge

Thomas Sandal

Lene Nonboe Andersen

Claus Dambmann

Tina Spendler

Joan Qi Si

Lisbeth Bech

Kim Uhre Hansen

Debbie Sue Yaver

Joel R Cherry

Hans Peter Heldt-Hansen

Sakari Kauppinen

Egon Nielsen

Kimberley M Brown

Allan Svendsen

Carsten Schau Andersen

Jesper Vind

Peter Kamp Hansen

Lene Venke Kofod

Ib Groth Clausen

Claus Von Der Osten

Noriko Tsutsumi

Inge Helmer Knap

John C Royer

Peter Bauditz

Marianne Thellersen

Karen Margrethe Oxenbo Slashedll

Carsten Mailand Hjort

Ivan Verner Diers

Martin Barfoed

Steen Troels Jorgensen

Lisbeth Hedegaard

Jens Sigurd Okkels

Masanobu Abo

Lone Dybdal

Flemming M Christensen

Titus Kretzschmar

Henrik Dalboege

Kim Clausen

Peter Rahbek Stergaard

Peter Rahbek &Oslash;stergaard

Lene Venke Kofoed

Dorte Aaby Petersen

Jeff Shuster

Mariko Okada

Satoshi Hirayama

Pau Ferrer

Martin Schulein

Shinobu Takagi

Sven Pedersen

Ole Kirk

Henrik Bisgard-Frantzen

Jan Lehmbeck

Tove Christensen

Charlotte Johansen

Jan Moller Mikkelsen

Lars Saaby Pedersen

Mogens Trier Hansen

Bjarne R&oslash;nfeldt Nielsen

Juan A Asenjo

Erik Gormsen

Rikako Taira

Kurt Dorreich

Jan Mo Mikkelsen

Iben Angelica No Slashedrrevang

Lisbeth Anker

Yukiko Takamura

Naoko Ikegami

Miyoko Hashida

Miyoko Hasida

Mary Ann Stringer

Thomas Schafer

Jens To Andersen

Kurt D Orreich

Stephen Christgau

Kaj Andre Holm

Demitris Savva

Jesper Haaning

Karen Margrethe Oxenb&oslash;ll

Iben Angelica N&oslash;rrevang

Thomas Sch&auml;fer

Jens T&oslash;nne Andersen

The present invention relates to a modified enzyme with lipolytic activity, a lipolytic enzyme capable of removing a substantial amount of fatty matter during a one cycle wash, a DNA sequence encoding said enzymes, a vector comprising said DNA sequence, a host cell harbouring said DNA sequence or said vector, and a process for producing said enzymes with lipolytic activity.

Lipolytic enzymes

The present invention relates to enzymes produced by mutating the genes for a number of subtilases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved autoproteolytic stability in comparison to their wild type parent enzymes.

Protease variants and compositions

The present invention relates to transglutaminases and transglutaminase preparations obtained from lower fungi belonging to the class Oomycetes and unprecedented high-level expression is achievable by growing these coenocytium forming organisms, especially the strainssp.,(or),and; and a recombinant transglutaminase has been cloned and expressed, the enzyme and enzyme preparations being useful for cross-linking proteins, e.g. in flour, baked products, meat products, fish products, cosmetics, cheese, milk products, gelled food products and leather finishing, or as a glutaminase, e.g. in bread and other baked glutein-containing food products.

Transglutaminase from oomycetes

The invention provides a novel method for down-regulating the biological activity of osteoprotegerin ligand (OPGL, TRANCE) thereby rendering possible the treatment/amelioration of diseases characterized by excessive loss of bone mass, e.g. osteoporosis. Down-regulation is effected by inducing an immune response against OPGL in an individual in need thereof. Immune responses can be raised by classical immunization with immunogenic variants of OPGL or by nucleic acid immunization where the nucleic acids encode the OPGL variant. The invention also pertains to compositions, polypeptides and nucleic acids useful in the invention, as well as to vectors and transformed host cells useful in the preparation thereof.

Method for down-regulating osteoprotegerin ligand activity

The present invention relates to a modified enzyme with lipolytic activity, a lipolytic enzime capable of removing a substantial amount of fatty matter a one cycle wash, a DNA sequence encoding said enzymes, a vector comprising said DNA sequence, a host cell harbouring said DNA sequence or said vector, and a process for producing said enzymes with lipolytic activity.

The present invention relates to transglutaminases and transglutaminase preparations obtained from lower fungi belonging to the class Oomycetes. Unprecedented high-level expression is achievable by growing these coenocytium forming organisms, especially the strains Pythium sp., (or ), and . Arecombinant transglutaminase has been cloned and expressed, the enzyme and enzyme preparations being useful for cross-linking proteins, e.g. in flour, baked products, meat products, fish products, cosmetics, cheese, milk products, gelled food products and leather finishing, or as a glutaminase, e.g. in bread and other baked glutein-containing food products.

The present invention relates to a 35 kDa enzyme exhibiting aminopeptidase activity which is derived from a fungal microorganism, a DNA construct comprising a DNA sequence encoding said enzyme, a recombinant expression vector comprising said DNA construct, and a cell comprising said DNA sequence. The present invention also provides a method for producing said enzyme exhibiting aminopeptidase activity, and an enzyme preparation comprising said enzyme, a bread-improving or dough-improving composition comprising the aminopeptidase of the invention. Finally the invention relates to the use of said enzyme exhibiting aminopeptidase activity or enzyme preparations or compositions thereof.

Enzymes with aminopeptidase activity

Lipolytic enzymes with high activity at alkaline pH in the absence of Ca can be obtained from filamentous fungi of the genera Gliocladium, Verticillium and Trichophaea and that the lipolytic enzymes are effective for improving the effect of detergents. The lipolytic enzymes have a good washing performance, as expressed by the hydrolysis of oil on textile swatches. The amino acid sequences of the lipolytic enzymes are highly homologous.

Alkaline lipolytic enzyme

Modified protease having improved autoproteolytic stability

The present invention relates to a DNA construct exhibiting &bgr;-1,3-glucanase activity, which DNA sequence comprises: a) the DNA sequence shown in SEQ ID No. 1 or SEQ ID No. 12, or b) an analogue of the DNA sequence defined in a), which i) is homologous with the DNA sequence defined in a), or ii) hybridizes with the same oligonucleotide probe as the DNA sequence defined in a), or iii) encodes a polypeptide which is homologous with the polypeptide encoded by a DNA sequence comprising the DNA sequence defined in a), or iv) encodes a polypeptide which is immunologically reactive with an antibody raised against the purified &bgr;-1,3-glucanase derived from,LLG109 encoded by the DNA sequence defined in a). The DNA construct may further encode a mannose binding domain. The invention also relates to a DNA construct encoding a mannose binding domain. Further the invention relates to an expression vector comprising said DNA constructs, a cell harbouring said DNA constructs or expression vectors, a method of producing the novel enzyme, a novel enzyme preparation containing said novel enzyme, the use of the enzyme for degrading or modification of &bgr;-glucan containing material.

Enzyme with &bgr;-1,3-glucanase activity

The present invention relates to polypeptides having laccase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides.

Purified Coprinus laccases and nucleic acids encoding same

Nucleic acids encoding polypeptides having laccase activity

The present invention relates to an enzyme exhibiting aminopeptidase activity, a method for producing said enzyme, an enzyme preparation containing said enzyme exhibiting aminopeptidase activity, and use of said enzyme for various industrial purposes.

An isolated polypeptide having &agr;-galactosidase activity and characterized as having a pH optimum in the range of 5.0-7.0, and a temperature optimum within the range of 50-70&deg; C. The &agr;-galactosidase is derived from

&agr;-galactosidase enzyme

A method for identifying a transglutaminase-producing microorganism based on a selective assay is disclosed.

Microbial transglutaminases, their production and use

Growing community of inventors

Birkeroed, Denmark

Torben Halkier