Pfenex Inc.

Torben Bruck

Russell J Coleman

Diane M Retallack

Adam Curry Chapman

Hongfan Jin

Provided herein are methods of production of recombinantasparaginase. Methods herein produce asparaginase having high expression levels in the periplasm or the cytoplasm of the host cell having activity comparable to commercially available asparaginase preparations.

Method for production of recombinantasparaginase

Provided herein are methods of production of recombinantasparaginase. Methods herein allow production of asparaginase inhost cells at high expression levels and having activity comparable to commercially available asparaginase preparations.

The present invention relates to the field of medicine, in particular, to the production of large amounts of a soluble recombinant polypeptide as part of a fusion protein comprising an N-terminal fusion partner linked to the polypeptide of interest.

Fusion partners for peptide production

Method for production of recombinant

Provided herein are methods of production of recombinantasparaginase. Methods herein allow production of asparaginase in Pseudomonadales host cells at high expression levels and having activity comparable to commercially available asparaginase preparations.

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Lakeside, CA, United States of America

Torben Bruck