The University of Texas System

Case Western Reserve University

Baylor College of Medicine

Tor Savidge

Jonathan S Stamler

Catherine Schein

Werner Braun

Petril Urvil

Emily Hollister-Branton

Dhananjaya Nauduri

Sara Dann

Numan Oezguen

Embodiments include methods for generating a metabolite profile of a stool sample and methods of assessing the status of a subject using the metabolic profile derived from a stool sample.

Methods and uses for metabolic profiling forinfection

Embodiments of the invention include methods and/or compositions for analysis of samples forinfection to determine whether or not an individual is at risk for having recurrentinfection or a CDI misdiagnosis. Methods include characterization of microflora composition from the gut, wherein alterations of the microflora gut composition are indicative of recurrence of infection. Methods include analysis of nucleic acids from the gut, such as 16S rRNA as being identifying of a particular bacteria in the analysis of bacterial populations of the gut.

[object Object]

Provided herein are methods for ameliorating the pathophysiology cysteine protease exotoxin comprising the step of administering to said individual an effective dose of an S-nitrosylating agent and an inositol phosphate or analog thereof.

S-nitrosylation of glucosylating toxins and uses therefor

Provided herein are analog and derivative compounds of inositol hexakisphosphate effective to treat ainfection and to neutralize the bacterial toxins produced by the same. In addition, methods of treating theinfection and for neutralizing its toxins with the compounds are provided.

Inositol hexakisphosphate analogs and uses thereof

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League City, TX, United States of America

Tor Savidge