Fibrotx Oü{umlaut Over ( )}

Protobios, LLC

Cellin Technologies Oue

Fibrotx Oü

Toomas Neuman

Kaia Palm

Jaak Vilo

Lagle Kasak

Meelis Kull

Mari-Liis Kruup

Ave Kris Lend

Balaji Rajashekar

Sulev Reisberg

Arno Pihlak

Martin Sauk

Gerli Viikmaa

Aram Kazarjan

Anri Kivil

Anti Alman

Anastassia Kolde

The present invention provides a diagnostic kit for detecting the presence or quantity of one or more test analytes within a test sample taken from a body surface of a mammal, the diagnostic kit comprising: a separate insert for a lateral flow device () comprising a membrane () fixed to a rigid support () and, the separate insert being configured to obtain the test sample; a lateral-flow assay device configured () to accept the separate insert (); a securing member () configured to releasably attach () the separate insert to a body surface of a mammal (); wherein the securing member () comprise an expandable layer () configured to apply pressure to the separate insert () thereby pressing the separate insert () against the body surface of the mammal ().

Lateral flow assay device

The present invention provides a dermal patch for selectively retaining one or more analyte(s) from a body of a subject comprising: a membrane layer () for retaining one or more analyte(s) from a body of a subject, with a first and a second side, wherein the first side is adapted to be in fluid communication with the skin of the subject; optionally holding means for securing the membrane layer in place; an adhesive layer (); and a backing layer; wherein between the backing layer and the membrane layer () there is an expandable layer () for applying pressure to the membrane layer.

Device to measure analytes in the skin

A method of forming a metadatabase of minimal epitope profiles including: performing antibody activity profiling from an immunoglobulin fraction of a plurality of samples to form a data set of peptide profiles for each sample, comparing peptide profiles across different samples, assigning a diagnosis or disorder to differentially expressed meta-profiles, constructing a meta-database containing minimal epitope clusters, constructing a database of peptide frequencies, aligning peptides to define the sequence of minimal epitope, verifying the minimal epitope by harboring a connected identifier, providing an enriched affinity sample, and providing a source data for metadatabase a database underlying it.

Peptide profiling and monitoring humoral immunity

The present invention relates to a simplified process, which is shorter in time, for propagation of proliferating cells, such as e.g. progenitor or stem cells, by means of a biphasic culturing system having a differentiation supporting component and a proliferation supporting component, and to the use of the stem cell cultures obtained in this way for cell therapy purposes. The present invention invention describes a method, which is highly efficient to prime stem or progenitor cells to differentiation using non-attachment matrices and differentiation supporting component. The cells produced therefrom may be used to treat a variety of neurodegenerative disorders.

Ex vivo progenitor and stem cell expansion and differentiation for use in the treatment of disease of the nervous system

Growing community of inventors

Tallinn, Estonia

Toomas Neuman