Eli Lilly and Company

Reilly Industries, Inc.

Avera Pharmaceuticals, Inc.

Wayne State University

University of Hawai'i

Tyligand Bioscience (shanghai) Limited

Tony Yantao Zhang

James A Aikins

Eric F Scriven

Yao-Chang Xu

Daniel Timothy Kohlman

Alexander Glenn Godfrey

John Cunningham O'Toole

Matthew Scott Thomas

Matthew Carl Allgeier

Jacob Luisi

Michael P Squillace

Robert Louis Ternik

Carrie Jannean Page

Tonya Lee Chalfant

Thomas M Wilson

John Robert Rizzo

Ramiah Murugan

Jeffrey Thomas Vicenzi

James G Keay

Michael A Staszak

John P Gardner

Barbara S Briggs

David A Hay

Boyu Zhong

Jerry Wayne Misner

Guangming Chen

Randal Scot Miller

John McNeill McGill

Milton Zmijewski, Jr

Scott Allan May

Jeffrey Forrester McKelvy

Yiju Cao

A gripping attachment () is disclosed which facilitates the handling of a medication bottle (). The medication bottle includes a container () having a cylindrical wall () extending parallel to a longitudinal axis. The container is closed at one end by a base wall () and has an opposed open end. The container receives a cap () on the open end to enclose the container. The gripping attachment comprises a sleeve portion () having a sleeve wall () defining an internal, cylindrical surface configured to removably attach to the container wall. The gripping attachment further comprises a leverage component connected to the sleeve portion to facilitate gripping the sleeve portion.

Gripping attachment for a bottle

A group of tropomyosin receptor kinase inhibitors including an amido-phenoxy-indazole structure fragment. These compounds show potent inhibitory effects on various oncogenic kinases, especially TRK, and thus can be used to treat tumors or cancers.

TRK inhibitors useful as anticancer drugs

The present invention relates to solid oral fixed dose compositions of metformin, atorvastatin, and valsartan, or their pharmaceutically acceptable salts, processes for the preparation thereof, and the use of the composition to treat certain diseases.

Pharmaceutical compositions

A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.

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The present invention relates to a one-pot process for preparing a compound of formula I: I; by reacting a compound of formula II with a compound of formula III: in the presence of a suitable solvent, a suitable base, a palladium catalyst and a suitable ligand.

Synthesis of 2-aryl-1-naphthol derivatives via a tandem palladium catalyzed arylation and dehydrogenation

Arylpiperazines having activity at the serotonin 1A receptor

The present invention provides a novel process for the preparation of substituted piperidine-4-ones useful as intermediates in the preparation of pharmaceuticals.

Preparation of substituted piperidin-4-ones

This invention provides processes for preparing intermediates useful for the preparation of cryptophycin compounds.

Stereoselective process for producing intermediates of cryptophycins

A process for resolving amino protected racemic 3-amino-2-methylpropionic acid which comprises the steps of: (1) reacting said amino protected acid with a protected amino group with an enantiomer of a chiral amine to form diastereomeric salts; (2) recrystallizing the diastereomeric salts from ethyl acetate to separate the diastereomeric salts into crystal fractions; and (3) releasing the resolved acid from the diastereomeric salt by treating the diastereomeric salt with a basic solution is disclosed. A process for the preparation of the cryptophycin molecules is also disclosed.

Optical resolution of aminoisobobutyric acid

The present invention is directed to a new process for the synthesis of vinyl sulfoxides, in particular diarylvinyl sulfoxides

Process for the synthesis of vinyl sulfoxides

This invention provides processes for preparing lactone intermediates useful for the preparation of pharmaceutical compounds such as tetrahydrolipstatin and cryptophycin compounds.

Process for preparing enollactone derivatives

The present invention relates to intermediates and processes for preparing benzothiophenes.

Processes for preparing benzothiophenes

Growing community of inventors

Indianapolis, IN, United States of America

Tony Yantao Zhang