New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery

New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery

Tony Chen

Suzanne Maher

Russell F Warren

Suzanne A Maher

Joseph David Lipman

Peter Torzilli

Kenneth Ng

Florian Wanivenhaus

An improved method of making, manufacturing and/or producing engineered orthopedic soft tissue including cartilage, meniscus, annulus fibrosus, and tendon/ligaments which results in engineered soft tissue in which the fibers are aligned the same or nearly the same as naturally occurring tissue. The present invention also includes molds and other apparatus for carrying out the methods of the invention and kits.

Method of making, manufacturing or producing orthopedic soft tissue

An improved new method of making a multi-component implant comprising a solid hydrogel, a porous hydrogel, and a porous rigid base suitable for implantation into a mammal, to treat, repair or replace defects and/or injury biological tissue as well as the implant made from the improved method. The invention also includes an improved method for making devices, constructs, and materials comprising a hydrogel and a porous rigid material. The invention also includes a mold and kits for performing the methods.

Method of and a mold for the manufacture, making and/or production of a multi-component implant, device, construct or material

An implant comprising at least three components, namely, a solid hydrogel, a porous hydrogel adjacent to or surrounding the solid hydrogel (together considered 'the hydrogel'), and a porous rigid base. The solid hydrogel and porous rigid base carry joint load, and the porous hydrogel layer and the porous rigid base allow for cellular migration into and around the implant. The invention is also a novel method of manufacturing the implant, a novel method of implanting the implant, and a method of treating, repairing or replacing biological tissue, more preferably musculoskeletal tissue, with the implant.

Multi-component non-biodegradable implant, a method of making and a method of implantation

An implant having at least three components, namely, a solid hydrogel, a porous hydrogel adjacent to or surrounding the solid hydrogel (together considered 'the hydrogel'), and a porous rigid base. The solid hydrogel and porous rigid base carry joint load, and the porous hydrogel layer and the porous rigid base allow for cellular migration into and around the implant. The invention is also a novel method of manufacturing the implant, a novel method of implanting the implant, and a method of treating, repairing or replacing biological tissue, more preferably musculoskeletal tissue, with the implant.

The present invention relates to a method of manufacture of an interconnected porous non-biodegradable polymer implant suitable for implantation into a mammal for the treatment, repair or replacement of defects or injury in musculoskeletal tissue, wherein the mechanical properties of the implant can be controlled by varying the concentration of the non-biodegradable polymer and/or varying the duration and number of freeze-thaw cycles and the interconnected porous non-biodegradable polymer implant has sufficient percent porosity and pore diameter to facilitate integration of cells and attachment within the mammal via ingrowth of surrounding tissue. The present invention also relates to an implant manufactured by the method.

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New Brunswick, NJ, United States of America

Tony Chen