Cedars-sinai Medical Center

Toni Rita Prezant

Shlomo Melmed

Anthony P Heaney

Nathan Fischel-Ghodsian

Disclosed is a method of inhibiting neoplastic cellular proliferation and/or transformation of mammalian breast or ovarian cells, including cells of human origin, in vitro or in vivo. The inventive method involves the use of a pituitary tumor transforming gene (PTTG)2 peptide, which has the ability to regulate endogenous PTTG1 expression and/or function in a dominant negative manner. In some embodiments, the invention is directed to gene-based treatments that deliver PTTG2-encoding polynucleotides to mammalian cells, whether in vitro or in vivo, to inhibit the endogenous expression of PTTG1. Other embodiments are directed to peptide-based treatments that deliver PTTG2 peptide molecules to the cells, which inhibit endogenous PTTG1 expression and/or PTTG1 function. Kits useful in practicing the inventive method are also disclosed.

Method of regulating biological activity of pituitary tumor transforming gene (PTTG)1 using PTTG2

Method for detection of mitochondrial nucleotide associated with predisposition for ototoxic deafness, especially deafness associated with the administration of aminoglycosides, is described.

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West Hills, CA, United States of America

Toni Rita Prezant