Pharmacyclics, Inc.

Institucio Catalana De Recerca I Estudis Avancats

Fundacio Privada Institut D'investigacio Oncologica De Vall Hebron

Toni Jauset González

Laura Soucek

Marie-Eve Beaulieu

Daniel Massó-Vallés

The invention relates to a polypeptide comprising or consisting of the polypeptide of SEQ ID NO: 1 wherein the residue X at position 89 of SEQ ID NO: 1 is not a cysteine, or a functionally equivalent variant of said polypeptide wherein the residue X at position 89 of SEQ ID NO: 1 is not a cysteine and their use in medicine, particularly in the prevention and/or treatment of cancer.

Methods and compositions for the treatment of cancer

Disclosed are methods of treating fibrosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of an ACK inhibitor (e.g., a BTK inhibitor, such as for example an irreversible BTK inhibitor, such as for example, ibrutinib).

Growing community of inventors

Lleida, Spain

Toni Jauset González