Massachusetts Institute of Technology

Schering Corporation

Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Tong Wang

Muriel Medard

Alan B Cooper

Gerald Wayne Shipps, Jr

Yongqi Deng

Ulric J Ferner

Neng-Yang Shih

Ronald J Doll

M Arshad Siddiqui

Alan W Hruza

Li Xiao

Kristin E Rosner

Robert Sun

James J-s Wang

Hugh Y Zhu

Patrick J Curran

Yang Nan

Youhao Dong

Viyyoor Moopil Girijavallabhan

Joseph P Vacca

James Han Wang

Vincent Stewart Madison

Joseph Michael Kelly

Jagdish A Desai

Craig Alan Coburn

Huw M Nash

Sunil Paliwal

Xiaolei Gao

Hon-Chung Tsui

David Allen Annis

Sobhana Babu Boga

Ahmed Abdi Samatar

Thomas G Steele

Mehul F Patel

Liang Zhu

Abdul-Basit Alhassan

Praveen K Tadikonda

Azim Alan Celebi

Gergely M Makara

Janet Popovici-Muller

Yiji Wu

Jagdish Desai

James Wang

Ahmed Samatar

Azim A Celebi

Multi-resolution encoded files are stored on a plurality of disk drives using systematic network coded storage. In some embodiments, the stored files are used to provide video streaming services for users.

Network coded storage with multi-resolution codes

Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

Compounds that are ERK inhibitors

Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substituents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

The present invention is directed to phenyl carboxamide compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease

The invention relates to the inhibition of hepatitis C virus (HCV) replication. In particular, embodiments of the invention provide compounds and methods for inhibiting HCV RNA-dependent RNA polymerase enzymatic activity. The invention also provides compositions and methods for the prophylaxis and treatment of HCV infection.

Pyrazolo[1,5a]pyrimidine compounds as antiviral agents

The present invention provides compounds of formula I wherein X and R&#x2013;Rare as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders using these compounds and compositions are also provided 

Substituted 5-oxo pyrazoles and [1,2,4]triazoles as antiviral agents

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Cambridge, MA, United States of America

Tong Wang