Glyconex, Inc.

Tong-Hsuan Chang

Jerry Ting

Shu-Yen Chang

Liahng-Yirn Liu

Mei-Chun Yang

Yu-Yu Lin

Yen-Ying Chen

Shu-Lun Tang

Sen-itiroh Hakomori

Chia-Hao Chang

Kazuko Handa

Mei-Chin Yang

Tsai-Hsia Hong

Ying-Jin Chen

Jaw-Yuan Wen

Liahng-Yim Liu

Ying-Zin Chen

Disclosed herein are humanized antibodies, antigen-binding fragments thereof, and antibody conjugates, that are capable of specifically binding to certain biantennary Lewis antigens, which antigens are expressed in a variety of cancers. The presently disclosed antibodies are useful to target antigen-expressing cells for treatment or detection of disease, including various cancers. Also provided are polynucleotides, vectors, and host cells for producing the disclosed antibodies and antigen-binding fragments thereof. Pharmaceutical compositions, methods of treatment and detection, and uses of the antibodies, antigen-binding fragments, antibody conjugates, and compositions are also provided.

Therapeutic antibodies

Disclosed herein are antibodies or antigen-binding portions thereof directed against extended Type I chain antigens, in particular extended Type I chain glycosphingolipids, and the uses of the antibodies or antigen-binding portions thereof in the diagnosis, amelioration, treatment or prevention of diseases or disorders in mammals, including humans, resulting from or associated with the improper activity/metabolism or the presence of extended Type I chain antigens, in particular extended Type I chain glycosphingolipids.

Antibodies against extended type 1 chain antigens, derivatives thereof and use

Human antibodies and antigen-binding portions of those antibodies that specifically bind extended Type I chain glycosphingolipids are provided.

Anti-extended type I glycosphingolipid antibody, derivatives thereof and use

Growing community of inventors

Taipei, Taiwan

Tong-Hsuan Chang