Baxter International Inc.

Baxter Healthcare Sa

Northwestern University

Baxalta Gmbh

Ton That Hai

Paul Jeffrey Sanders

Sujatha Karoor

Leo Martis

Cong Jiang

Paul J Soltys

Salim Mujais

Rahul Tandon

Stavroula Morti

Brian Donovan

Mari Katada

Luis Lu

Deanna J Nelson

Mark Nordhaus

Phillip Byron Messersmith

Kent Lane Lurvey

Tadas Stanislovas Sileika

Vadim V Krongauz

John-Bruce Devault Green

Timothy Michael Fulghum

Tuan Bui

David Eugene Pereira

Ozlem Yardimci

Ana Srnak

Lecon Woo

Larry Richard Brown

Michael Dockal

David R Lamb

Bennett Melnick

Birendra K Lal

Craig L Sandford

Shmuel Sternberg

Hsinjin E Yang

Rosa Yeh

Robin Gail Pauley

Robert A Clarke

Arounaguiry Ambroise

Dustin Christopher Cawthon

Sivaramakrishnan Krishnamoorthy

Michael Tung-Kiung Ling

Guohan Yang

William S Hoerle

Jie Li

Ashok K Khanna

Alexander Savitski

Nicklaus J Kirichkow

Kenneth Glen Suh

Cliff Holmes

Catherine Quinn

James E Kipp

Timothy N Estep

Sabine Knappe

Susanne Till

Ben Melnick

Fritz Scheiflinger

Prasad Dande

Fritz Schleiflinger

Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.

System, method, and composition for removing uremic toxins in dialysis processes

The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

Immobilization of an active agent on a substrate using compounds including trihydroxyphenyl groups

A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.

Antimicrobial housing and cover for a medical device

The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

Immobilization of an active agent on a substrate

Therapeutic compositions capable of removing excess nitric oxide are provided. The therapeutic compositions include nitronyl nitroxide monoradicals, B12 derivatives, flavonoid derivatives, the like and combinations thereof. The therapeutic compositions can be utilized in a number of suitable applications, such as to prevent or treat intradialytic hypotension during dialysis.

Nitric oxide scavengers

Method and composition for removing uremic toxins in dialysis processes

The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.

Polymeric benzyl carbonate-derivatives

Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.

Growing community of inventors

Round Lake, IL, United States of America

Ton That Hai