Dsm N.v.

U.S. Philips Corporation

Pfizer Corporation

Bone Care International, Inc.

Plus Chemicals, B.v.

Ton Rene Vries

Hans Wijnberg

Quirinus B Broxterman

Kees Pouwer

Lumbertus A Hulshof

Erik Van Echten

Michael John Munchhof

Mark Edward Flanagan

Egbert Willem Meijer

Edsko E Havinga

Hans Wynberg

Glenn E Wilcox

Jose Nieuwenhuijzen

Kornelis L Pouwer

Christian Koecher

Venetka Ivanova Kalkman-Agayn

Mieke Ivanova Sibeyn

Wijnand Sjourd Faber

The present application discloses compounds of the formula 

Chiral salt resolution

The invention relates to 1,3-disubstituted-3-oxopropane-1-sulfonic acids and sulfonates and enantiomerically inriched forms thereof. The invention further relates to the use of these enantiomerically inriched compounds to resolve mixtures of enantiomers, in particular mixtures of enantiomers of amino-functionalized compounds.

3-oxopropane-1-sulphonic acids and sulphonates

A diastereomer complex obtained via a process for the separation of enantiomers is disclosed, wherein separation can be rapidly effected such that enantiomers are obtained with high e.e. values. The process permits the separation of mixtures of enantiomers in which more than one resolving agent is used, of which at least one resolving agent is optically active, and which yields a diastereomer complex containing at least two resolving agents in optically active form. The process provides for, inter alia, a diastereomer complex having at least three compounds of which at least two compounds are resolving agents in optically active form, and at least one compound is an enantiomer in optically active form. Also provided is a diastereomer complex having at least three compounds of which at least one compound is a resolving agent in optically active form, and at least two compounds which are enantiomers in optically active form.

Process for the separation of a mixture of enantiomers

The present invention provides a method for preparing a novel class of vitamin D compounds in which the C-25 or equivalent position has a double bond. In addition, the side chain is optionally extended by one or two methylene or methyne groups. The compounds prepared by the method of the present invention are of value as prodrugs for active 1&agr;, 24-dihydroxylated vitamin D compounds.

Method for making hydroxy-25-ene-vitamin D compounds

A process has been provided to produce semi synthetic statins, as for instance simvastatin with a high yield, for another statin, preferably a naturally occurring statin, as for instance lovastatin. Also a number of novel intermediate compounds, prepared during said process, has been provided.

Process for the production of semi synthetic statins via novel intermediates

A diastereomer complex obtained via a process for the separation of enantiomers is disclosed, wherein separation can be rapidly effected such that enantiomers are obtained with high e.e. values. The process pets the separation of mixtures of enantiomers in which more than one resolving agent is used, of which at least one resolving agent is optically active, and which yields a diastereomer complex containing at least two resolving agents in optically active form. The process provides for, inter alia, a diastereomer complex having at least three compounds of which at least two compounds are resolving agents in optically active form, and at least one compound is an onantiomer in optically active form. Also provided is a diastereomer complex having at least three compounds of which at lea one compound is a resolving agent in optically active form, and at least two compounds which are enantiomers in optically active form.

The polymers are prepared by using the new intermediate product which forms a polymeric precursor, and which is converted into the desired heterocyclic polymer by ring closure.

Method of manufacturing conductive heterocyclic polymers by reacting new

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Groningen, Netherlands

Ton Rene Vries