Nano Precision Medical, Inc.

Tomoyuki Yoshie

Adam D Mendelsohn

Kathleen E Fischer

Wouter Erik Roorda

Embodiments of the invention include devices, compositions and methods for the controlled release of therapeutic substances, such as drugs. Control over the rate of release of the therapeutic substances from the devices is achieved by the use of nanoporous membranes in which the pore size is matched to the molecular diameter of the therapeutic substances. Some embodiments of the invention achieve zero-order release by the use of membranes with a pore diameter that is more than five times the Stokes' diameter of the therapeutic substance released.

Drug delivery device

The present invention provides a method for controlling the internal diameter of nanopores to afford nanopore membranes with a zero-order rate of release of a therapeutic agent.

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Emeryville, CA, United States of America

Tomoyuki Yoshie