Arqule, Inc.

Daiichi Sankyo Company, Limited

Tomoyuki Tsunemi

Jean-Marc Lapierre

Kiyoshi Nakayama

Yusuke Ota

Hiroaki Inagaki

Sudharshan Eathiraj

Takayuki Momose

Brian Schwartz

Nivedita Namdev

Yoshihiro Shibata

Masanori Ichikawa

Noriyasu Haginoya

Masami Ohtsuka

Hironao Saito

Hironori Matsunaga

Manish Tandon

Craig G Bates

Masahiro Ota

Takashi Odagiri

The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Amino-pyrrolopyrimidinone compounds and methods of use thereof

The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof

A compound represented by formula (I) having mTOR inhibitory activity or a pharmacologically acceptable salt thereof.

Imidazopyridin-2-one derivatives

A compound represented by formula (I) having mTOR inhibitory activity or a pharmacologically acceptable salt thereof. 

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Tokyo, Japan

Tomoyuki Tsunemi