Ajinomoto Co., Ltd.

Tomoyuki Tagami

Yasuhiro Tanaka

Manabu Suzuki

Masahiro Murata

Tadakiyo Nakagawa

Tatsuhiro Yamada

Kohichi Fujita

Yuka Ikenoue

Hideki Matsumoto

Akira Chiba

Ariko Kodaira

Yoshitomo Chujo

Shunsuke Fukuda

Yoshitomo Chujoh

Syunsuke Fukuda

A pharmaceutical composition containing a heterocyclic compound of the formula (I) wherein each symbol is as defined in the specification, an isomer thereof, a solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient has a superior TNF-&#x3b1; production suppressing action. Accordingly, it is useful for the prophylaxis or treatment of various diseases caused by abnormal production of TNF-&#x3b1;.

Heterocyclic compounds

The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituent(s), Yand Yare nitrogen atoms etc., an isomer or solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient.

Growing community of inventors

Kanagawa, Japan

Tomoyuki Tagami