Astellas Pharma Gmbh

Canon Kabushiki Kaisha

Cytokinetics, Inc.

Origin Electric Company, Limited

Oki Data Corporation

Other

Tdk Corporation

Japan Science and Technology Agency

Tomoyuki Saito

Hiroaki Tanaka

Bradley Paul Morgan

Pu-Ping Lu

Fady Malik

Luke W Ashcraft

Takashi Kamikubo

Scott E Collibee

Yuki Emoto

Masanori Miura

Jeffrey Warrington

Susumu Yamaki

Ippei Sato

Yuji Matsushima

Yasuhiro Shiina

Kayoko Mihara

Marc Andrew Garard

Junichi Hirate

Kiyoshi Masuda

Hiroshi Kiyohara

Munemichi Ohe

Takaaki Ishida

Shuichi Tokuda

Masahiro Nakamura

Takayuki Suzuki

Takafumi Shimizu

Shunichiro Matsumoto

Takatoshi Kanayama

Toshirou Yoshiike

Shigeo Matsui

Tatsunori Shimonishi

Yuki Sawada

Hideki Kubota

Takeyuki Nagashima

Kazuhiro Yokoyama

Hidenori Azami

Hisao Hamaguchi

Hitoshi Takamura

Kei Ohnuki

Masuo Okada

Kazuyuki Kuramoto

Takashi Shin

Naoto Katoh

Shigetoshi Kikuchi

Yusuke Wakisaka

Masayuki Ogawa

Takuto Yamashita

Masahiro Sudo

Chiharu Mori

Scott Emile Collibee

Jeffrey Michael Warrington

Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast skeletal muscle sarcomere through one or more of fast skeletal myosin, actin, tropomyosin, troponin C, troponin I, and troponin T, and fragments and isoforms thereof. The tetrahydroisoquinoline derivative compounds can thus be used as an agent for preventing or treating 1) neuromuscular disorders, 2) disorders of voluntary muscle, 3) CNS disorders in which muscle weakness, atrophy, and fatigue are prominent symptoms, 4) muscle symptoms stemming from systemic disorders, and 5) dysfunctions of pelvic floor and urethral/anal sphincter muscle.

Tetrahydroisoquinoline derivatives

To allow short time spreading for adhesive, verifying whether the adhesive is spread out to a member end. In obtaining a bonded member by applying the adhesive to a surface of one of two members and bonding the members with a member bonding device, a tilt adjusting device acquires with a camera an image of spreading state of the adhesive in the members' bonding surface, and adjusts the tilt of the bonded member when a non-spreading part of the adhesive between ends of the bonded member and the adhesive has a size bias so that the adhesive moves to the larger side of the part, and a spreading adjustment device controls a pushing amount and a pushing time interval of a pressing-side member to adjust spreading of the adhesive so that the part size reduces to a predetermined size depending on the part size acquired with the camera, and cures the adhesive in the bonded member edge with the non-spreading part eliminated.

Member bonding apparatus and method

[Problem] To provide a compound useful as a MTand/or MTreceptor agonist. [Solution] The present inventors have studied on MTand/or MTreceptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished. That is, a compound represented by formula (I) or a salt thereof according to the present invention has a MTand/or MTreceptor agonistic activity and has a low ability of migrating into central nervous system. Therefore, the compound or a salt thereof can be used as a peripheral MTand/or MTreceptor agonist, and therefore can be used as a therapeutic and/or prophylactic agent for urinary incontinence, particularly stress urinary incontinence and mixed urinary incontinence. 

Indole compound

Compounds of formula (I) and salts thereof: wherein the variables are defined herein, are useful for the treatment of breast cancer.

Bicyclic nitrogen-containing aromatic heterocyclic amide compound

The present invention relates to indole carboxamide compounds of formula (I) or a salt thereof wherein R, R, R, R, R, R, Rand Rhave the meanings as indicated herein, and are MT1 and/or MT2 receptor agonists useful for treating and/or preventing urological diseases.

Indole carboxamide derivative

A printing apparatus includes a printing unit, a first and second conveying units conveying a printing medium, a driving unit driving the conveying units and a control unit controlling the driving unit. A load mutually acting on the conveying units through the medium in a conveyance state by the conveying units is recursively calculated for each predetermined conveyance unit while setting the initial value to 0. The driving unit is controlled based on the calculation result at the time of the transition to suppress a fluctuation in a conveyance amount at the time of the transition of the conveyance state of the medium from the conveyance state by the conveying units to a conveyance state only by the second conveying unit.

Printing apparatus and control method

A method and an apparatus is capable of manufacturing a bonded member faster without a protrusion of the adhesive. An adhesive in an amount which becomes predetermined thickness when two rectangular members are bonded together is applied in advance on bonded surfaces of the two members, the applied adhesives of the two members are brought into contact with each other and one of the two members is made to slide along the bonded surface and the two members are overlapped, a portion of the adhesive which is likely to protrude from an end portion of the two overlapped members is cured before occurrence of a protrusion of the adhesive, and the two overlapped members are pressurized while the protrusion of the adhesive is prevented so as to manufacture a bonded member.

Method and apparatus for manufacturing bonded member

A printing apparatus includes a printing unit, first and second conveying units conveying a printing medium, a driving unit driving the first and second conveying units, and a control unit controlling the driving unit. The conveyance state of the printing medium makes transition from a first conveyance state in which the printing medium is conveyed only by the first conveying unit to a second conveyance state in which the printing medium is conveyed by both the first and second conveying units. The control unit controls the driving unit based on a fluctuation in a load that mutually acts between the first and second conveying units through the printing medium to suppress a fluctuation in a conveyance amount at the time of the transition of the conveyance state from the first conveyance state to the second conveyance state.

Printing apparatus, conveying apparatus, and control method

The conveyance apparatus includes a first conveyance unit configured to convey a sheet in a conveyance direction, and a second conveyance unit disposed on a downstream side of the first conveyance unit in the conveyance direction and configured to convey the sheet in the conveyance direction. The conveyance apparatus corrects a rotational amount of each conveyance unit using a correction value dedicated to each rotational phase of each conveyance unit for each conveyance state, in a first conveyance state in which the first conveyance unit is operative to convey the sheet, a second conveyance state in which the first and second conveyance units are cooperative to convey the sheet, and a third conveyance state in which the second conveyance unit is operative to convey the sheet.

Conveyance apparatus and recording apparatus

Based on a conveyance amount in a second conveyance state where a sheet is conveyed by both a first conveyance unit and a second conveyance unit being a conveyance amount obtained by subjecting a conveyance amount in a first conveyance state where the sheet is conveyed only by the first conveyance unit and a conveyance amount in a third conveyance state where the sheet is conveyed only by the second conveyance unit to weighted average with difficulty of slipping of the first or second conveyance unit to the sheet as a weighting coefficient, a remaining conveyance amount is calculated from any two conveyance amounts from among conveyance amounts of the first, the second and the third conveyance states, and a correction value for conveyance is set from the calculated conveyance amount.

Conveyance apparatus and method for calculating conveyance correction value

It can prevent extension of the time required for bonding, even when relatively large members are bonded. a bonded member manufacturing apparatus comprises a first holderfor holding a first member D, a second holderfor holding a second member E, an application devicefor applying the intermediate substance G to a first bonded surface Df, a moving devicefor moving the first holderand/or the second holder, and a controller. The controller controls the first holder, the second holderand the moving deviceso that a first extended plane De and a second extended plane Ee are arranged such that the first extended plane De and the second extended plane Ee oppose each other in parallel and such that a range where the first bonded surface Df overlaps with the second bonded surface Ef is equal or smaller than a predetermined range when viewed in a direction of the thickness, and then so that the first member D is moved relatively to the second member E in a direction that the range where the first bonded surface Df overlaps with the second bonded surface Ef gradually increases when viewed in the direction of the thickness while maintaining a distance between the first extended plane De and the second extended plane Ee.

Method of manufacturing bonded member and bonded member manufacturing apparatus

An information processing apparatus includes a receiving unit for receiving a control command including first identification information; an identification information obtaining unit for obtaining the first identification information from the control command thus received; a storage unit for storing second identification information related to a specific user; an identification information comparing unit for comparing the first identification information with the second identification information; and a control command processing unit for performing a first process when the first identification information matches to the second identification information and performing a second process when the first identification information does not match to the second identification information.

Printing method

Growing community of inventors

Tokyo, Japan

Tomoyuki Saito