Nissan Chemical Industries Limited

Tomoyuki Matsuda

Kazuhiko Ohrai

Takumi Okada

Osamu Uesugi

Yukohiro Shigeta

Toru Tsukagoshi

Takayuki Nagatsuka

Norio Hashimoto

This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein Rand Rare independently of each other hydrogen atom, Calkyl group or Caryl group, Ris hydrogen atom or Calkylcarbonyloxy group, or together with Rforms a bond, Ris hydrogen atom, or together with Rforms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CRR, NR, O, S, SO or SO, Ris hydrogen atom or Calkyl group, Ris hydrogen atom, Calkyl group, Ccycloalkyl group, Ccycloalkenyl group, amino group, Calkylamino group, di-Calkylamino group, Carylamino group, Cheteroarylamino group, Caryl group, Cheteroaryl group or Cheterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.

Tricyclic benzopyrane compound

This invention relates to benzopyran compounds of formula (I) wherein X is NR, Y is a bond, SO or SO, Z is Calkyl group or phenyl group, W is hydrogen atom, hydroxy group, Calkoxy group, a halogen atom, Calkyl group or Calkylsulfonylamino group, Rand Rare independently of each other Calkyl group, Ris hydrogen atom, hydroxy group or methoxy group, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CRR, NR, O, S, SO or SO, Ris hydrogen atom or Calkyl group, Ris hydrogen atom, Calkyl group, Ccycloalkyl group, Ccycloalkenyl group, Caryl group or Cheteroaryl group. These compounds are useful as an anti-arrhythmic agent.

Benzopyran compound

This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein Rand Rare independently of each other hydrogen atom, Calkyl group or Caryl group, Ris hydrogen atom or Calkylcarbonyloxy group, or together with Rforms a bond, Ris hydrogen atom, or together with Rforms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CRR, NR, O, S, SO or SO, Ris hydrogen atom or Calkyl group, Ris hydrogen atom, Calkyl group, Ccycloalkyl group, Ccycloalkenyl group, amino group, Calkylamino group, di-Calkylamino group, Carylamino group, Cheteroarylamino group, Caryl group, Cheteroaryl group or Cheterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent. 

Tricyclic benzopyran compound as anti-arrhythmic agents

Growing community of inventors

Minamisaitama-gun, Japan

Tomoyuki Matsuda