Japan Tobacco Inc.

Tomoyuki Manabe

Hiroshi Ueno

Tetsuya Iida

Koichi Suzawa

Susumu Katoh

Tomoya Miura

Kouichi Aoyagi

Shintaro Hirashima

Kentaro Sakurai

Takashi Shimada

Kazuhiro Tsutsumi

Shin-Ya Sasaki

Yuki Fujishima

Pyrazole compounds substituted with heteroaryl or pharmaceutically acceptable salts thereof that have an SGLT1 inhibitory activity and are useful for a drug, pharmaceutical compositions comprising the same, and pharmaceutical use thereof are disclosed. Specifically, a compound of Formula [X]: wherein Ris hydrogen or halogen, Ris Calkyl or halo-Calkyl, Ring Het is substituted pyridyl or optionally substituted pyrazinyl, pyrimidinyl, or pyridazinyl, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising it, and pharmaceutical use thereof is provided.

Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof

The spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof 

Spiro compounds and pharmaceutical use thereof

Growing community of inventors

Osaka, Japan

Tomoyuki Manabe