The General Hospital Corporation

The Charles Stark Draper Laboratory, Inc.

Tomoyuki Maemura

Jeffrey T Borenstein

Joseph P Vacanti

Eli J Weinberg

Mohammad Reza Kaazempur-Mofrad

Kevin R King

Jennifer Ogilvie

Chiao-Chun Wang

Young-Moon Michael Shin

Alexander Sevy

Osamu Ishii

Eli The Charles Stark Draper Lab Inc Weinberg

Osamu Ishi

Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

Fabrication of vascularized tissue using microfabricated two-dimensional molds

Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

Fabrication of tissue lamina using microfabricated two-dimensional molds

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Boston, MA, United States of America

Tomoyuki Maemura