Kotobuki Seiyaku Co. Ltd.

Tomoyuki Kawai

Tsuyoshi Tomiyama

Akira Tomiyama

Naoto Ueyama

Motoharu Sonegawa

Shuuichi Wakabayashi

Tadashi Shirai

Takashi Yanagisawa

Hiromi Baba

Yumiko Ichikawa

Makoto Haketa

New therapeutic agents of cycloheptimidazole derivatives are disclosed, which are represented by the following formula or its alkali-addition salts. ##STR1## (wherein R.sub.1 represents H or isopropyl group; R.sub.2 represents a lower alkyl; R.sub.3 represents a carboxylic acid or tetrazole group. A and A.sub.1 are substituted groups at 4 or 8 position and A.sub.1 is a hydrogen or hydroxy group when A is a hydrogen or A and A.sub.1 is an oxo group. The dotted line '- - - -' is two double bonds or saturated single bonds). These compounds are useful as anti-hypertensive or anti-congestive heart failure agents.

Cycloheptimidazole derivatives, method of manufacturing the same and

Derivatives of cyclic guanidine are disclosed, which are represented by the following formula:

Cyclic guanidine derivatives, anti-ulceratives and method of

Cyclic guanidine derivatives, anti-ulceratives and methods of

New quinazoline derivatives are disclosed, as represented by the following formula: ##STR1## wherein A is hydrogen atom or lower alkyloxy group; R.sub.4 is hydrogen atom, a lower alkyl, lower alkyloxy or a halogen atom group. Y is hydrogen atom, lower alkyloxy, sulfamoyl or Y and R.sub.4, taken together, are joined to form --O--CH.sub.2 --CH.sub.2 --O--; Z is a 4-oxopiperidino, 4-thioxopiperidino, 4-oximepiperidino, 4-O-loweralkyl-oxime-piperidino, 4-O-(3-lower alkyl-2-hydroxypropyl)-oxime-piperidino, 4-O-(3-lower alkylamino-2-hydroxypropyl)-oxime-piperidino or 4-O-(3-N'-lower alkyl, N'-benzylamino-2-hydroxypropyl)-oxime-piperidino group. These compounds are useful as anti-hypertensive agents.

Quinazoline derivative and anti-hypertensive agents

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Nagano, Japan

Tomoyuki Kawai