Otsuka Pharmaceutical Company, Limited

Tomoyuki Kawaguchi

Yoshimasa Nakano

Seiji Sato

Kazumi Kondo

Masahiro Murakami

Satoshi Hayakawa

Hitoshi Tone

Shigeharu Tamada

Youichi Taniguchi

Yoshihiko Ito

Shinji Nishitani

Katsumi Tamura

Taketoshi Izawa

Michiharu Sugawara

Hideaki Sato

Yasumitsu Tamura

Setsuyoshi Uetsuki

Shuji Akai

Hiromichi Fujioka

Katsuhide Matoba

Toshinori Kaneyasu

Akira Wada

Yasuyuki Kita

The novel indole derivatives and salts thereof represented by the general formula (1) ##STR1## possess, for example, an inhibitory effect against superoxide (O.sub.2.sup.-) released from the macrophage cells of guinea pig by stimulation and an anti-albuminuria activity against Masugi nephritis, and are useful in various clinical fields as an agent for preventing and treating diseases and cases associated with the above superoxide radical, for example, autoimmune diseases (e.g. rheumatism), arteriosclerosis, ischemic disease, ischemic encephalopathia, hepatic insufficiency and renal insufficiency, and also as an agent for preventing and treating nephritis.

Indole derivatives

A novel pyrazinoxide compound of NF-1616-904 having the formula (1), ##STR1## prepared by hydrolyzing the intermediate compound of NF-1616-902 which is separated from a culture broth of a microorganism belonging to the genus Thielavia. The pyazinoxide compound of NF-1616-904 possess biological and pharmacological activities, and is useful agent for preventing and treating diseases caused by superoxide radicals (O.sub.2.sup.-), and nephritis.

Novel pyrazinoxide compound of NF-1616-904 and a pharmaceutical

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Tokushima, Japan

Tomoyuki Kawaguchi