Mitsui Chemicals, Inc.

Schering Aktiengesellschaft

Bayer Schering Pharma Ag

Bayer Intellectual Property Gmbh

Tomoyuki Ando

Tsuneji Suzuki

Katsutoshi Tsuchiya

Seiichi Kobayashi

Masakazu Murakami

Eishi Tanaka

Yoshinori Shiraishi

Osamu Nakanishi

Akiko Saito

Takashi Yamashita

Hironori Komatsu

Hiroki Ishibashi

Hitoki Miyake

Hideki Umetani

Hidetoshi Hayashi

Osamu Kohgo

Takeshi Nakamura

Toshihiro Oikawa

Atsushi Sakuma

Hironori Kuboi

Yasushi Fukuiri

Toshifumi Yamaki

Mamoru Takashina

Kazuhiko Togashi

Jens Geisler

Nobuyuki Fukazawa

Tsuyoshi Inoue

Tadashi Araki

Kiyoshi Ito

Tamotsu Asano

Michael Gottfried

Ichirou Ikeda

Junya Fujiwara

Masahiko Ishibashi

Matthias Schneider

Kyoko Maruyama

Takahiro Yamauchi

Ikuo Sakai

Masahiro Sakabe

Masaru Honjo

Gabriele Winter

Joji Suzuki

Hirokazu Awano

Tsuchiya Katsutoshi

Provided is a polymerizable composition including an alkyne compound represented by the following general formula (1): 

Polymerizable composition and novel alkyne compound

The crystalline Polymorph B of N-(2-aminophenyl)-4-[N-(pyridine-3-yl)methoxy-carbonyaminomethyl]benzamide (MS-275) of formula I is described, as well as the process for the production of said compound, and its use as a medicament for the treatment of selected diseases.

N-(2-aminophenyl)-4-[N-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (MS-275) polymorph B

Disclosed is a metal compound represented by the following formula (0): 

Metal compound, polymerizable composition containing the same, resin, method for producing the resin, and use of the resin

A process for producing bis(thietanylthio)dithiastannolane of the following formula: involving the reaction of tetrakis(thietanylthio)tin having the following formula: with 1,2-ethandiethiol.

Process for producing bis(thietanylthio)dithiastannolane

Polymerizable compositions containing at least one metal thietane compound represented by general formulas (110), (201) or (120), respectively, wherein said formulas are as follows: and wherein the identified moieties and n, p, q and r are defined.

Metal thietane compound, polymerizable composition containing the compound, resin and use of the resin

The composition of the present invention contains a product having a thiol group obtained by reacting an Sb or Bi oxide or an Sb or Bi halide with at least one kind of polythiol compounds selected from compounds having at least two thiol groups in a molecule.

Composition, polymerizable composition, resin, optical component, and method for producing the composition

The additive for a polymerizable composition according to the present invention contains a compound represented by the general formula (a). In the general formula (a), R represents a saturated hydrocarbon group having 1 to 3 carbon atoms. M represents Sn, Sb, Bi, or Ge. m represents 0 or 1. R and M are not directly bonded when m is 0. n represents an integer of 1 to 3. X represents a monovalent linking group, and a plurality of X may be the same as or different from each other. When two or more linking groups X are bonded with the metal atom M, the linking groups X may combine together to form a ring. 

Additive for polymerizable composition, polymerizable composition containing the same and use of the polymerizable composition

Disclosed is a compound represented by the following general formula (1), 

Compound, polymerizable composition, resin, and use of the composition and the resin

Disclosed is a metal thietane compound represented by the following general formula (120),  (wherein, in the above general formula (120), M is a member selected from the group consisting of Bi, Sb, Ti, Zr and Ta; Xand Xare each independently a sulfur atom or an oxygen atom; Ris a divalent organic group; the bond between M and T shown by a dotted line and a solid line represents a single or double bond; m is an integer of 0 or 1 or more; n is the number of valence of M; and p is an integer of equal to or more than 1 and equal to or less than n, provided that when r is 1, q is 0 and Y is a monovalent inorganic or organic group; when r is 1 and n-p-q is 2 or more, a plurality of Ys contained are each independently selected from monovalent inorganic or organic groups; when r is 1 and n-p-q is 2 or more, a plurality of Ys may be bonded to each other to form a ring containing M; when r is 2, n-p-q is 1 or 2 and Y is a divalent group; when r is 2 and n-p-q is 2, two Ys may form a ring together with two Ms; and when r is 2 and q is 2, a plurality of Ts contained are each independently selected from inorganic or organic groups).

A method of treating a malignant tumor selected from the group consisting of leukemia, colorectal cancer, ovarian cancer, oral cancer, lung carcinoma, breast carcinoma, prostate carcinoma, and melanoma by administering to a patient in need thereof an effective amount of at least one compound represented by formula (1) wherein A, X, Q, R, and n are defined herein.

Cell differentiation inducer

The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma. 

Cell differentiation inducer, benzamide compounds

A novel gluconate dehydratase derived fromand a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-deoxyaldonic acid can be efficiently produced.

Gluconate dehydratase

Benzamide derivatives and pharmaceutical compositions containing same

Growing community of inventors

Omuta, Japan

Tomoyuki Ando