Tanabe Seiyaku Company, Limited

Tomoyasu Taniguchi

Junko Mizukami

Masahiko Kisumi

Saburo Komatsubara

A method for identifying or screening an agonist for or antagonist to a peroxisome proliferator activated receptor (PPAR) which comprises allowing a test cell and a substance to be tested to coexist, and detecting a change in a ligand-dependent interaction between the PPAR and a coactivator in the test cells due to the substance to be tested by measuring the expression of a reporter gene as an index.

Method for identifying or screening agonist and antagonist to PPAR

A novel microorganism of the genus Escherichia containing a hybrid plasmid prepared by integrating a plasmid with a deoxyribonucleic acid carrying the gene for aspartase which is obtained from a microorganism of the genus Escherichia. An industrially advantageous method for producing L-aspartic acid comprising contacting a culture of the novel microorganism, microbial cells collected from the culture or a processed material of the microbial cells with fumaric acid and ammonia to produce L-aspartic acid and then collecting L-aspartic acid thus produced is also disclosed.

Growing community of inventors

Toda, Japan

Tomoyasu Taniguchi