Kyowa Hakko Bio Co., Ltd.

Otsuka Pharmaceutical Factory, Inc.

University Public Corporation Osaka

Tomoya Yokoi

Hiroshi Nagano

Masahiro Abe

Kazunari Fukumoto

Takayuki Shimizu

Akihiro Fujimoto

Kenta Fukumoto

Kikue Mase

Sotaro Sanpei

Hiroshi Ooshima

Koichi Igarashi

An object of the present invention is to provide a crystal of an amino acid salt of HMB which is easy to handle and has high solubility, and to provide a method for producing the same. According to the present invention, the crystal of an amino acid salt of HMB can be precipitated by dissolving an amorphous amino acid salt of HMB in a solvent containing alcohol and stirring or allowing the solvent to left stand. In addition, the crystal of an amino acid salt of HMB can be precipitated by concentrating an aqueous HMB solution of an amino acid salt which has a pH of 2.5 to 11.0.

Crystal of amino acid salt of 3-hydroxyisovaleric acid and production method thereof

An object of the present invention is to provide a crystal of 3'-sialyllactose (hereinafter, referred to as 3SL), which is easily handled, and has high storage stability at normal temperature as well as under high temperature conditions, and provide a process for producing the same. The present invention relates to a 3SL sodium salt n-hydrate (wherein n represents any number of 0 to 9, and when n is 0, it is referred to as 3SL sodium salt anhydrate) and a process for producing the same.

Crystal of 3'-sialyllactose sodium salt n-hydrate, and process for producing same

An object of the present invention is to provide a crystal of 6'-sialyllactose (hereinafter, referred to as 6SL) sodium salt, which is easily handled, and has high storage stability at normal temperature as well as under high temperature conditions, and provide a production process thereof. The present invention relates to a crystal of 6SL sodium salt and a process for producing the crystal.

Crystal of 6'-sialyllactose sodium salt, and process for producing same

The present invention provides a crystal of a monovalent cation salt of 3-hydroxyisovaleric acid (hereinafter, referred to as HMB), which is excellent in solubility and easy to handle, and a process for producing the crystal. A crystal of a monovalent cation salt of HMB is precipitated in an aqueous HMB solution containing a monovalent cation-containing compound and having a pH of 4.0 to 9.0, and the crystal of a monovalent cation salt of HMB is thereafter collected from the aqueous solution.

Crystal of monovalent cation salt of 3-hydroxyisovaleric acid and process for producing the crystal

The present invention provides a crystal of reduced glutathione that is stable, and is easy to process, and a method for producing the crystal. According to the present invention, a crystal of a metal salt of reduced glutathione is produced by suspending an amorphous solid of a metal salt of reduced glutathione in a hydrophobic organic solvent, and adding water to the resulting suspension to precipitate a crystal of a metal salt of reduced glutathione.

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Tokyo, Japan

Tomoya Yokoi