Toppan Printing Co., Ltd.

Japan As Represented by Director-general of National Institute of Infectious Diseases

Tomoya Sumida

Masaki Kono

Yoshihiro Kodama

Yumiko Ikeda

Ryoichi Asai

Kazuhiko Shiomitsu

Hiroyuki Kato

Yumiko Yamada

Seishiro Naito

An operation tool for a fluid injector includes a selective movement mechanism which moves the fluid injector between a first protruding position and a second protruding position in a housing of an outer cylinder. When the fluid injector is at the first protruding position, microneedles of a multi-microneedle device are protruded out to a first distance from the first open end. When the fluid injector is at the second protruding position to discharge a fluid via the microneedles, the microneedles are protruded out to a second distance from the first open end, which is shorter than the first distance. The selective movement mechanism includes a rotational-linear movement conversion mechanism which moves the fluid injector between the first and second protruding positions along a longitudinal center line of the outer cylinder based on a direction and an amount of rotation of the outer cylinder relative to the fluid injector.

Operation tool for fluid injector using multi microneedle device

A puncture injection instrument including a hollow needle body including a substrate having a first surface and a second surface opposite to the first surface, the hollow needle body having one or more projections which are formed on the first surface and each have a through hole penetrating from a distal end of the projection to the second surface of the substrate, and one or more probes positioned outside a region where the one or more projections are formed. The one or more probes include an ultrasound probe or an optical coherence tomography probe.

Puncture injection instrument

A hollow needle device includes a main body having a first surface on which hollow acicular bodies are formed and a second surface opposite to the first surface, a main body supporting member having an opening that accommodates the main body and including a drop-out prevention mechanism for holding the main body that has the hollow acicular bodies being protruded from one end of the opening, an injector supporting member disposed detachably in the opening of the main body supporting member, and a liquid-tight structure that establishes liquid tightness between the injector supporting member and an inner surface that defines the opening in the main body supporting member. The injector supporting member has a connection hole to which a protrusion of an injector is detachably connected liquid tightly to guide an injection solution supplied from the injector into the opening via the protrusion of the injector.

Hollow needle device

A microneedle set including a microneedle injection device that introduces a liquid to a skin of a body part, and a piercing assisting tool fixable to the body part. The microneedle injection device includes a hollow needle shaped body having a projection in an end portion thereof and a through hole connected to the projection such that the liquid passes through the through hole and is released from a tip portion of the projection, and a supply device that supplies the liquid to the hollow needle shaped body. The piercing assisting tool includes a fixing part which has an aperture formed therein and fixes a position of the aperture on the body part, and a cover connected to a peripheral portion of the aperture such that the aperture is opened or closed by the cover.

Microneedle set

An operation tool for a fluid injector includes an outer cylinder having a housing extending from a first open end to a second open end, and a selective transfer mechanism provided on the outer cylinder. The selective transfer mechanism moves the fluid injector from an initial position to a first protrusion position and then to a second protrusion position in the housing of the outer cylinder. When the fluid injector is at the initial position, the multi-microneedle device has microneedles retracted from the first open end and positioned inside the housing, when the fluid injector is at the first protrusion position, the microneedles are protruded out to a first distance from the first open end, and when the fluid injector is at the second protrusion position, the microneedles are protruded out to a second distance from the first open end. The second distance is shorter than the first distance.

Operational instrument for fluid injector using multi-microneedle device

A drug administration device includes a substrate having a first surface, a projection extending from the first surface, and a solid drug. One direction that intersects with the first surface is a first direction, and one direction that extends along the first surface is a second direction. A groove serving as a receiving section is formed in the projection. The groove defines a cavity recessed in the first direction toward the substrate and extends in the second direction to open to a section of the peripheral surface of the projection. The drug is received in the groove.

Drug administration device, and manufacturing method for drug administration device

A needle-shaped body including a support section having a tubular shape with a center axis being a reference line, the support section having a proximal end and a distal end, a support substrate positioned in the support section and movable in a direction along the reference line, a needle section positioned on a main surface of the support substrate and protruding in a direction from the proximal end toward the distal end, a connecting section that detachably attaches the support substrate to the support section, and a guiding section that guides the support substrate along the reference line.

Needle-shaped body

A method of manufacturing a needle shaped body includes forming on a surface of a substrate a needle shaped portion having a bottomed hole that extends from a tip to the substrate, contacting the tip of the needle shaped portion with a surface of a liquid in an atmosphere at a first pressure lower than atmospheric pressure, increasing the first pressure to a second pressure while the tip is in contact with the surface of the liquid such that the liquid is filled into the bottomed hole, and freeze-drying the liquid filled in the bottomed hole.

Needle shaped body and method for manufacturing needle shaped body

A microneedle puncture instrument includes a pinch section including a first pinch element and a second pinch element arrayed in an array direction and configured to individually pinch the skin in a pinch direction, which intersects with the array direction, the first pinch element and the second pinch element being connected to each other with a distance therebetween maintained within a predetermined range; and a puncture section configured to puncture the skin while pinching the skin in the pinch direction at a position between the first pinch element and the second pinch element in the array direction, the puncture section including a microneedle for puncturing the skin and a support portion that supports the microneedle.

Microneedle puncture instrument

A method for manufacturing a hollow needle-shaped body includes producing a needle-shaped body having a substrate and a projection on a first surface of the substrate, and applying a laser beam to a second surface of the substrate opposite to the first surface such that a through hole that penetrates through the substrate and the projection is formed. The substrate and the projection are comprised of crystallized polyglycolic acid.

Method for manufacturing hollow needle-shaped body, and hollow needle-shaped body

Operation tool for fluid injector using multi-microneedle device

An operation tool includes a mechanism sequentially moving the injector in a space of an outer cylinder among an initial position in which needles of a main body of the device are retracted inside the space, a first position in which the needles protrude to the outside by a first distance, and a second position in which needles protrude to the outside by a second distance shorter than the first distance. Fluid flows from the injector through the needles in the second position. The mechanism has a unit forcing the injector toward the initial position by a magnetic force, first and second stoppers which can be selectively extended/retracted with respect to the outer peripheral wall of the outer cylinder, and an engaging portion which is selectively engaged with these stoppers on the outer peripheral wall of the injector and selectively arranging the injector in the above three positions.

Growing community of inventors

Taito-ku, Japan

Tomoya Sumida