Seikagaku Corporation

Olympus Corporation

Tomoya Sato

Susumu Hashimoto

Takashi Saito

Hidekazu Iwaki

Katsuichi Imaizumi

Suguru Okaniwa

Kyosuke Mizuno

Katsuya Takahashi

Yukihiro Matsuyama

Takehiko Ito

Sachiko Asatori

Akira Koushinbou

Noriko Oshima

Kota Fujiwara

Eiji Nogami

The present invention relates to an aqueous composition which comprises chondroitin sulfate, hyaluronic acid, and a pharmaceutically acceptable carrier, and which can be stored at room temperature. The present invention also relates to an aqueous composition which comprises chondroitin sulfate, hyaluronic acid, sorbitol, and a pharmaceutical acceptable carrier.

Stabilized aqueous composition comprising chondroitin sulfate and hyaluronic acid

An image processing apparatus including a processor comprising hardware. The processor being configured to: divide an imaging signal that is obtained by capturing an image of an inside of a subject into a first base component and a detail component, the first base component corresponding to an illumination component of an object, the detail component corresponding to a reflectance component of the object; generate a second base component by performing a color enhancement process on the first base component for increasing color gradation in a predetermined color space; and synthesize the second base component and the detail component to output a synthesized signal. Where the color enhancement process is an enhancement processing on the first base component for extending a color distribution range of at least one component of an L component, an a component, and a b component in a Lab color space.

Image processing apparatus and image processing method

An image signal processing device includes: a base component extractor that generates an original base component signal; a base component adjuster that generates a first base component signal by performing weighted average processing; a detail component extractor that generates a first detail component signal based on the first base component signal; a relative emphasizer that outputs a second base component signal and a second detail component signal by relatively emphasizing the first detail component signal to the first base component signal; a combiner that generates a combined image signal by combining the second base component signal and the second detail component signal; and a storage that stores control parameters regarding similarity between the image signal and the first base component signal. The base component adjuster generates the first base component signal by performing the weighted average processing by using a weight coefficient determined in accordance with selected control parameter.

Image signal processing device, image signal processing method, and program

An image processing apparatus includes: a dividing processing circuit configured to divide an imaging signal that is obtained by capturing an image of inside of a subject into a first base component and a detail component, the first base component corresponding to an illumination component of an object, the detail component corresponding to a reflectance component of the object; a color enhancement processing circuit configured to generate a second base component by performing a color enhancement process on the first base component, the color enhancement process being a process of increasing color gradation of a mucosa color in a predetermined color space; and a synthesizing circuit configured to synthesize the second base component and the detail component to output a synthesized signal.

An endoscope apparatus includes a detecting section to which an observation image of a subject is sequentially inputted, the detecting section being configured to detect a characteristic region in the observation image based on a predetermined feature value concerning the observation image, and an emphasis processing section configured to apply, when the characteristic region is continuously detected in the detecting section, emphasis processing of a position corresponding to the characteristic region to the observation image of the subject inputted after elapse of a first predetermined time period from a time when the characteristic region is detected.

Endoscope apparatus

An image signal processing apparatus includes: circuitry including: a mode setting circuitry configured to change a mode to one of a first mode and a second mode; a dividing circuitry configured to divide an input image signal into a base component signal and a detail component signal when the mode setting circuitry sets the first mode; a first tone compressing circuitry configured to perform a tone compression process on the base component signal to generate a compressed base component signal; a synthesizing circuitry configured to generate a synthetic image signal based on the detail component signal and the compressed base component signal; and a second tone compressing circuitry configured to perform a tone compression process such that tone of the input image signal becomes approximately equal to tone of the compressed base component signal when the mode setting circuitry sets a second mode.

Ultrasound observation device, operation method of image signal processing apparatus, image signal processing method, and computer-readable recording medium

An image processing device includes: an HDR image generating unit configured to generate an HDR image signal by first high dynamic range combining of a first signal including first image data and a second signal including second image data; a tone compressing unit configured to generate a first tone-compressed image signal to be displayed by performing tone compression processing on the HDR image signal generated by the HDR image generating unit; and a color correcting unit configured to generate a second tone-compressed image signal by second high dynamic range combining of at least the first and second signals based on the first tone-compressed image signal.

Image processing device and imaging system

An endoscope system includes: a signal processing apparatus that performs processing on an output signal outputted from an endoscope; a detecting section configured to detect a type of the endoscope; a function setting section configured to set a plurality of functions in the endoscope system; an input section configured to input data to the function setting section; an output section configured to output a list of setting states of the plurality of functions to a display section; and a storing section configured to store recommended setting data corresponding to the plurality of functions, wherein the function setting section sets the signal processing apparatus to selected one of the setting corresponding to the type of the endoscope and a setting recommended by the recommended setting data, according to an input from the input section, and sets the plurality of functions according to the type of the endoscope.

Endoscope system

The present invention provides a nucleus pulposus filler or the like which is to be packed into an area in deformed intervertebral disc wherein normal nucleus should be located and can be stabley maintained for a long time More preferably, the present invention provides a nucleus pulposus filler comprising a crosslinked chondroitin sulfate as an active ingredient. The photocrosslinked chondroitin sulfate is preferably the following one: a photocrosslinked chondroitin sulfate obtainable by freezing a photoreactive chondroitin sulfate-containing solution comprising: a photoreactive chondroitin sulfate to which a photoreactive group is bound; an aqueous solvent capable of dissolving the photoreactive chondroitin sulfate; and any one substance selected from the group consisting of an alcohol having aqueous solvent miscibility, a surfactant, and a cheleting agent; irradiating the resulting frozen product with light; and then melting the frozen product. The filler can be provided as a kit by packing it into a container from which the filler can be pushed out.

Nucleus pulposus filler

A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtaining the polysaccharide sponge. The process includes simplified steps requiring no removal of solvent, and has such an advantage that impurities are easily removed therefrom.

Crosslinked polysaccharide sponge

A photocrosslinked polysaccharide pseudo-sponge exhibiting a low swelling property and a high degradation ability in vivo while retaining a suitable strength. The polysaccharide pseudo-sponge is produced by a crosslinking reaction of a photoreactive polysaccharide obtained by introducing a photoreactive group into a polysaccharide, and exhibits a low swelling property and a blue dextran-low dyeaffinity.

Polysaccharide pseudo-sponge

A photoreactive polysaccharide which comprises a polysaccharide bound to a glycidyl ester via a covalent bond, a photocrosslinked-polysaccharide prepared by using the photoreactive polysaccharide, and medical products comprising the photocrosslinked-polysaccharide.

Photoreactive polysaccharide, photocrosslinked polysaccharide product and method of making same and medical materials made from the crosslinked polysaccharide

A photocrosslinked polysaccharide pseudo-sponge exhibiting a low swelling property and a high degradation ability in vivo while retaining a suitable strength. The polysaccharide pseudo-sponge is produced by a crosslinking reaction of a photoreactive polysaccharide obtained by introducing a photoroactive group into a polysaccharide, and exhibits a low swelling property and a blue dextran-low dyaffinity.

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Tokorozawa, Japan

Tomoya Sato