University of Massachusetts

Boston Scientific Scimed, Inc.

Tomoya Higashihara

Rudolf Faust

Mark W Boden

Marlene C Schwarz

Frederick H Strickler

Umaprasana Ojha

The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as 'click' chemistry linkages, and combinations of two or more types of such linkages.

Copolymers having polyisobutylene and biodegradable polymer segments

The present invention provides copolymers which include a plurality of constitutional units that correspond to at least one cationically polymerizable isomonoolefin species and a plurality of constitutional units that correspond to at least one anionically polymerizable monomer species selected from the group consisting of monomers of formula (I): wherein R, R, R, R, n, p, M, X, and L are defined herein. The present invention also provides methods for making and using (e.g., in articles of manufacture such as medical devices) the copolymers of the present invention.

Organometallic-polyisomonoolefin block copolymers

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Tokyo, Japan

Tomoya Higashihara