Banyu Pharmaceutical Co. Ltd

Tomoshige Numazawa

Norikazu Otake

Kazuhito Noguchi

Yoshio Ogino

Kenji Matsuda

Hideki Kurihara

Akira Naya

Toshifumi Kimura

Yufu Sagara

Toru Fujikawa

Minaho Uchiyama

This invention relates to compounds which exhibit selective muscarinic Mreceptor antagonism, have little side effects, are suitable for inhalation therapy and are useful as treating agents of respiratory system diseases, of the general formula (I);  [in which A signifies a group expressed by a formula (a) or (b); Ar signifies optionally substituted aryl or heteroaryl; Band Bsignify aliphatic hydrocarbon; Rsignifies fluorine-substituted cycloalkyl; R, Rand Rsignify lower alkyl, single bond or alkylene bonded to B, or Rand Rare united to signify alkylene; Rand Rsignify hydrogen, lower alkyl, or a single bond or alkylene bonded to B; Rsignifies hydrogen, lower alkyl or a group expressed as &#x2014;N(R)R; and Xsignifies an anion].

Ester derivatives

This invention relates to compounds which are represented by the general formula [I] [in which A stands for a group of the following formula [a] or [b]  The compounds of the invention exhibit selective antagonism to muscarinic Mreceptors, and therefore are useful as safe and effective agents showing little side effect, for treating diseases of the respiratory, urinary and digestive systems.

Amide derivatives

This invention relates to compounds which exhibit selective muscarinic Mreceptor antagonism, have little side effects, are suitable for inhalation therapy and are useful as treating agents of respiratory system diseases, of the general formula (I);  Ar signifies optionally substituted aryl or heteroaryl; Band Bsignify aliphatic hydrocarbon; Rsignifies fluorine-substituted cycloalkyl; R, Rand Rsignify lower alkyl, single bond or alkylene bonded to B, or Rand Rare united to signify alkylene; Rand Rsignify hydrogen, lower alkyl, or a single bond or alkylene bonded to B; Rsignifies hydrogen, lower alkyl or a group expressed as &#x2014;N(R)R; and Xsignifies an anion].

This invention relates to compounds which exhibit selective muscarinic Mreceptor antagonism, have little side effects, are suitable for inhalation therapy and are useful as treating agents of respiratory system diseases, of the general formula (I);

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Tsukuba, Japan

Tomoshige Numazawa