Kyowa Hakko Kirin Co., Limited

Kyushu University

Kyowa Kirin Co., Ltd.

Tomonori Tawara

Yoshimasa Inagaki

Tsuguo Kubota

Shinichiro Takayanagi

Koichi Akashi

Yoshikane Kikushige

Shin-ichiro Takayanagi

Hitomi Tomura

Disclosed are an anti-human TIM-3 antibody having high ADCC activity or antibody fragment thereof by screening a monoclonal antibody or antibody fragment thereof which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure and exhibits ADCC activity; a hybridoma which produces the antibody; a DNA encoding the antibody; a vector comprising the DNA; a transformant which is obtainable by introducing the vector; a method for producing the antibody or the antibody fragment thereof which comprises using the hybridoma or the transformant; and a therapeutic agent and a diagnostic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

Anti-TIM-3 antibody

The present invention provides an antibody to human IL-3R&#x3b1; chain, which does not inhibit IL-3 signaling and binds to B domain of the human IL-3R&#x3b1; chain but does not bind to C domain of the human IL-3R&#x3b1; chain; a composition for preventing or treating a blood tumor in which a cell expressing IL-3R&#x3b1; is found in bone marrow or peripheral blood of a subject, which comprises the antibody to human IL-3R&#x3b1; as an active ingredient; and a method for treating a blood tumor in which a cell expressing IL-3R&#x3b1; is found in bone marrow or peripheral blood, which comprises administering, to a subject, a composition comprising the IL-3R&#x3b1; antibody as an active ingredient.

Polynucleotide encoding antibody to human IL-3 receptor alpha chain

Antibody to human IL-3 receptor alpha chain

The present invention provides an anti-human TIM-3 antibody having high ADCC activity or antibody fragment thereof by screening a monoclonal antibody or antibody fragment thereof which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure and exhibits ADCC activity; a hybridoma which produces the antibody; a DNA encoding the antibody; a vector comprising the DNA; a transformant which is obtainable by introducing the vector; a method for producing the antibody or the antibody fragment thereof which comprises using the hybridoma or the transformant; a therapeutic agent and a diagnostic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

Growing community of inventors

Tokyo, Japan

Tomonori Tawara