Otsuka Pharmaceutical Company, Limited

Tomonori Shibata

Minoru Okada

Masaya Kato

Tetsuyuki Uno

Norifumi Sato

Junpei Haruta

Hidetaka Hiyama

Hideki Kitagaki

The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein Ris an aryl group which may have one or more substituents; Ris an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents; and W is a divalent group represented by &#x2014;Y-A- or or &#x2014;Y&#x2014;C(&#x2550;O)&#x2014; wherein Yis a group such as &#x2014;C(&#x2550;O)&#x2014;, Ais a group such as a lower alkylene group, and Yis a group such as a piperazinediyl group. The oxazole compound has a specific inhibitory action against phosphodiesterase 4.

Oxazole compound and pharmaceutical composition

The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein Ris an aryl group which may have one or more substituents; Ris an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents; and W is a divalent group represented by &#x2014;Y-A- or &#x2014;Y&#x2014;C(&#x2550;O)&#x2014; wherein Yis a group such as &#x2014;C(&#x2550;O)&#x2014;, Ais a group such as a lower alkylene group, and Yis a group such as a piperazinediyl group. The oxazole compound has a specific inhibitory action against phosphodiesterase 4.

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Ako, Japan

Tomonori Shibata