Yoshitomi Pharmaceutical Industries, Ltd.

Welfide Corporation

Tomonori Imayoshi

Michio Terasawa

Takanori Oe

Tadashi Mishina

Koji Teshima

Tsuneo Fujii

Tetsuya Tahara

Kazuyuki Kawasaki

Tsuguo Ikebe

Hiroyuki Sueoka

Mitsuyoshi Yasumoto

Hiroshi Yuki

Yukihiro Yasunaga

Kazuyuji Kawasaki

An external preparation for topical administration which aims at inhibiting rejection reactions at organ or bone marrow transplantation or treating autoimmune diseases or allergic diseases and contains as the active ingredient 2-amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol or a pharmaceutically acceptable acid addition salt thereof.

External preparation of 2-amino-2-(2-(4-octylphenyl)ethyl) propane-1,3-diol or pharmaceutically acceptable salts thereof for topical administration

Topical administration of

Benzopyranopyridineacetic acid ester compounds of the formula: ##STR1## wherein R.sup.1, and R.sup.2 and R.sup.3 independently represent hydrogen or C.sub.1-4 alkyl; and n is 1 or 2, and their pharmaceutical use are disclosed. These compounds possess antiinflammatory, analgesic and antipyretic activities with less adverse action on the gastrointestinal tract.

Benzopyranopyridineacetic acid ester compounds and their pharmaceutical

A pyrazolopyridine compound of the formula: ##STR1## or a salt thereof, wherein each symbol is as defined in the specification. Said compounds exhibit antiinflammatory, analgesic, antipyretic, antiallergic, antiarthritic, antirheumatic activities or inhibitory activities on platelet aggregation.

Pyrazolopyridine compounds, their preparation and use as platelet

Purine derivative and pharmaceutical composition

3-Indolecarboxamide compounds of the formula: ##STR1## inclusive of pharmaceutically acceptable acid addition salt and/or hydrate forms thereof, wherein R.sup.1 is C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl-C.sub.1-8 alkyl, allyl, propargyl, or phenyl or phenyl-C.sub.1-4 alkyl which may be optionally substituted, on the benzene ring, by at least one substituent selected from the group consisting of halogen, trifluoromethyl, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; R.sup.2 is H or C.sub.1-6 alkyl; R.sup.3 is H, halogen, C.sub.2-6 alkanoyloxy, benzoyloxy, C.sub.1-4 alkoxy, benzyloxy, hydroxy or C.sub.1-4 alkyl; R.sup.4 is H, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or hydroxy; R.sup.5 is H or C.sub.1-4 alkoxy; A is ethylene or trimethylene, which may be optionally substituted by C.sub.1-4 alkyl; n is zero, 1 or 2; and m is zero or 1, are useful as drugs for the prevention and treatment of various allergic diseases.

Anti-allergic 3-indolecarboxamides

Growing community of inventors

Oita, Japan

Tomonori Imayoshi