Mitsui Chemicals, Inc.

Tomonori Hidesaki

Tadashi Araki

Seiichi Watanabe

Kiyoteru Nagahara

Mitsuo Koito

Keita Nishida

Ryota Fujii

Anjali Madhavan

Su Sun Chong

Yoshiko Matsumoto

Akiko Natsuji

Hiroshi Shimizu

Daisuke Mochizuki

Satoshi Yamasaki

Hitoshi Takahashi

Toshihiko Nakagawa

Hiroshi Takeuchi

Daisuke Hasegawa

Mitsufumi Wada

Goro Kuwamura

Takashi Morishige

Nozomi Takebayashi

Kuniaki Sato

Tomokazu Shirai

Koh Amano

Chikara Furusawa

Takashi Hirasawa

Toshihiro Tateno

Ayako Endo

Dominik Lukas Jürgen-Lohmann

Tomomi Sakai

Disclosed is an acetyl-CoA-producing microorganism, which is obtained by imparting malate thiokinase and malyl-CoA lyase enzymatic activities to a microorganism having none of the following (a), (b), (c) or (d), without imparting any of (a), (b), (c) or (d), or, even when one or more of (a), (b), (c) or (d) are imparted, not allowing the functions thereof to be exerted: (a) a carbon dioxide fixation cycle having an enzymatic reaction from malonyl-CoA to malonate semialdehyde or 3-hydroxypropionate, (b) a carbon dioxide fixation cycle having an enzymatic reaction from acetyl-CoA and COto pyruvate, (c) a carbon dioxide fixation cycle having an enzymatic reaction from crotonyl-CoA and COto ethylmalonyl-CoA or glutaconyl-CoA or (d) a carbon dioxide fixation cycle having an enzymatic reaction from COto formate.

Microorganism for production of chemicals derived from acetyl-CoA

This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.

DNA encoding novel enzyme having D-serine synthase activity, method of producing the enzyme and method of producing D-serine by using the same

An acetyl-CoA producing microorganism obtained by imparting at least one enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism that does not have any of the following (a), (b), (c), (d) or (e): (a) a carbon dioxide fixation cycle including an enzymatic reaction from malonyl-CoA to malonate semialdehyde or 3-hydroxypropionate; (b) a carbon dioxide fixation cycle including an enzymatic reaction from acetyl-CoA and COto pyruvate; (c) a carbon dioxide fixation cycle including an enzymatic reaction from crotonyl-CoA and COto ethylmalonyl-CoA or glutaconyl-CoA; (d) a carbon dioxide fixation cycle including an enzymatic reaction from COto formate; or (e) at least one selected from the group consisting of malate thiokinase and malyl-CoA lyase.

Microorganism having carbon dioxide fixation cycle introduced thereinto

An acetyl-CoA-producing microorganism, which is capable of efficiently synthesizing acetyl-CoA using carbon dioxide, and a substance production method using the same are provided. An acetyl-CoA-producing microorganism including an acetyl-CoA production cycle obtained by imparting at least one type of enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism.

Microorganism having carbon dioxide fixation pathway introduced thereinto

A mutant lysine decarboxylase produced by replacing at least one of the amino acids in SEQ ID NO:4 with another amino acid.

Method for producing 1,5-pentamethylenediamine, mutant lysine decarboxylase, method for producing 1,5-pentamethylene diisocyanate and method for producing polyisocyanate composition

In a method for producing 1,5-pentamethylenediamine, a lysine decarboxylase-expressing microorganism that is subjected to a treatment is used.

Method for producing 1,5-pentamethylenediamine, 1,5-pentamethylenediamine, 1,5-pentamethylene diisocyanate, method for producing 1,5-pentamethylene diisocyanate, polyisocyanate composition, and polyurethane resin

Disclosed is a method for producing a &#x3b2;-amino acid comprising a step of synthesizing a &#x3b2;-amino acid from an &#x3b1;-amino acid in the presence of an amino acid aminomutase. In this method, a &#x3b2;-amino acid is precipitated as a solid in the reaction solution.

Method for producing &#x3b2;-Phenylalanine

This invention relates to DNA encoding an enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.

Growing community of inventors

Singapore, Singapore

Tomonori Hidesaki