Dai Nippon Printing Co., Ltd.

Tomonori Akai

Shigehiro Ueno

Naoki Yokoyama

Yasuhiro Iizumi

Takuma Baba

Kei Imai

Masanori Kagota

Yoshio Aikawa

Masaki Ohtake

Satoshi Sugimura

Masato Okada

Seiji Take

Takuya Higuchi

Masaya Shimogawara

Katsuyuki Motai

Yuya Takasugi

The object of the present invention is to provide a cell culture vessel having a plurality of microwells, which allows to identify the position of a microwell by observing it under a microscope without moving a viewing position, which has identifiers to be easily disposed to the microwells. The present invention is directed to a cell culture vessel comprising a bottom and a sidewall, in which the bottom has a cell containing section in which a plurality of microwells for containing cells are disposed, identifiers are disposed in the vicinities of the plurality of microwells so as to make pairs in individual microwells, and the relative position of each of the identifiers to a partner microwell varies in every pair.

Cell culture vessel

Provided is a sample image management system that uses a cell culture vessel including a plurality of microwells and a plurality of first identifiers provided to the respective microwells in pairs. The sample image management system analyzes, in an enlarged sample image including a pair of the first identifier and the microwell, the microwell and the first identifier, and associates at least position information on the microwell with the enlarged sample image.

Sample image management system and sample image management program

An object of the present invention is to provide a method for efficiently obtaining mammalian embryos having high conception rates. A first aspect of the present invention is a method for selecting a mammalian embryo prepared by in vitro culture from a fertilized egg, comprising a step of selecting an embryo using two or more of the following indicators: the time from fertilization to the completion of first cleavage; the morphology at a stage after first cleavage and before second cleavage; the morphology at a stage after third cleavage and before fourth cleavage; and the amount of oxygen consumed at the early blastocyst stage, the blastocyst stage, or the expanded blastocyst stage.

Method for producing embryos by in vitro culture, and method, apparatus, and system for selecting embryos

An object of the present invention is to provide a means for efficiently obtaining mammalian embryos having high conception rates. A first aspect of the present invention is a method for selecting a mammalian embryo prepared by in vitro culture from a fertilized egg, comprising a step of selecting an embryo using two or more of the following indicators: the time from fertilization to the completion of first cleavage; the morphology at a stage after first cleavage and before second cleavage; the morphology at a stage after third cleavage and before fourth cleavage; and the amount of oxygen consumed at the early blastocyst stage, the blastocyst stage, or the expanded blastocyst stage.

A QD protecting material having high compatibility with a binder component in a luminescent layer. The luminescent layer contains, as a part of its chemical structure, a compound containing a moiety A having a sum atomic weight MA of 100 or more and quantum dots protected by a protecting material, the protecting material contains, as a part of its chemical structure, a linking group connected to a quantum dot surface and a moiety B that has a sum atomic weight MB of 100 or more, satisfies a relationship between MB and MA represented by |MA&#x2212;MB|/MB (2, and satisfies the requirement that the sum atomic weight MB is larger than one-third of the molecular weight of the protecting material, and a solubility parameter SA of the moiety A and a solubility parameter SB of the moiety B satisfy a relationship represented by |SA (SB| (2.

Light emitting device having quantum cut dots with a protecting material and prolonged drive lifetime and good color purity

This invention provides a means for cell migration assays by regulating the cells adhered to a substrate so that they migrate to a given region, which is a substrate used for cell culture comprising: a base material comprising a conductive region and an insulating region provided thereon and cell-adhesive regions and non-cell-adhesive regions provided in the conductive region and the insulating region, respectively, wherein a cell-adhesive region is positioned adjacent to a non-cell-adhesive region in the conductive region, and a cell-adhesive region is positioned adjacent to a non-cell-adhesive region in the insulating region.

Substrate used for cell migration assays and method for cell migration assays

Provided is a biosensor that makes it possible to detect the electrical properties of a bio-related material contained in an analyte fluid such as an aqueous solution placed on a sensitive membrane and to observe the bio-related material at a high magnification with an observation device such as a microscope. The biosensor comprises: a substrate, a transparent semiconductor filmlaminated on the substrate, a source electrodeand a drain electrodeformed at both ends of the transparent semiconductor film, an insulating filmlaminated so as to cover the transparent semiconductor filmand the source electrodeand the drain electrodes, a sensitive membranelaminated on the insulating film, and a partitionthat is formed at both ends of the sensitive membraneto retain an analyte fluid, such as an aqueous solution or liquid culture containing a sample, on the sensitive membraneand to retain the analyte fluidin a specific region so that the bio-related materialcan be placed on the sensitive membrane

Field effect transistor type biosensor

This invention provides a means for modifying surface properties of a cell culture substrate under specific conditions, to thereby regulate regions to which cells are allowed to adhere or are not allowed to adhere, depending on cell type. This invention relates to a method of cell culture comprising steps of: applying a positive potential to a conductive region of a substrate comprising a base material having a conductive region and a non-cell-adhesive membrane coupled thereto with the aid of silane, so as to separate the non-cell-adhesive membrane from the substrate; and culturing cells in a region from which the non-cell-adhesive membrane has been separated.

Method of cell culture

The present invention provides an EL device that contains a quantum-dots-containing layer in which quantum dots hardly coagulate even under high-temperature conditions, e.g., at a temperature of 90&#xb0; C. or more, that has a good performance even if heat treatment was carried at a high temperature in its production process, that can retain its emission characteristics for a prolonged period of time, and that has high durability. An electroluminescent device comprises a pair of electrodes, and an electroluminescent layer containing at least a luminescent layer, situated between the electrodes. The luminescent layer contains quantum dots whose surfaces are protected by one or more protective materials. At least one of the protective materials has a glass transition temperature and a melting point of 90&#xb0; C. or more.

Electroluminescent device

An electroluminescent device comprising a pair of electrodes, and an electroluminescent layer containing at least a luminescent layer, situated between the electrodes. The luminescent layer has a matrix material containing at least one organic compound, and quantum dots whose surfaces are protected by a protective material and that are dispersed in the matrix material. The protective material contains a first protective material. The absolute value of the ionization potential Ip(h), the absolute value of the electron affinity Ea(h), and the band gap Eg(h) of the first protective material, the absolute value of the ionization potential Ip(m), the absolute value of the electron affinity Ea(m), and the band gap Eg(m) of the organic compound, and the band gap Eg(q) of the quantum dots fulfill all of the conditions (A) to (C): (A) Ip(h)&#x3c;Ip(m)+0.1 eV, (B) Ea(h)&#x3e;Ea(m)&#x2212;0.1 eV, and (C) Eg(q)&#x3c;Eg(h)&#x3c;Eg(m).

The present invention provides an electroluminescence device which can overcome a drawback that a light emitting layer deteriorates when a cathode layer is formed on the light emitting layer and has no decline in the original function; and a production method which is suitable for producing such an electroluminescence device. An electroluminescence device has a laminated structure wherein an anode layer, a light emitting layer, a charge transporting protection layer, and a cathode layer are successively formed on a substrate, in which the charge transporting protection layer comprises a transparent insulating material, or a transparent insulating material and a metal.

Electroluminescence device and functional device

An object of the present invention is to provide an EL element, which is with a problem of the EL layer deterioration caused at the time of forming a cathode layer on an EL layer resolved, and without the decline of the original functions; and a production method suitable for producing such an EL element. The object has been achieved by providing an EL element having a lamination structure with an anode layer, an EL layer, a charge transporting protection layer and a cathode layer formed in this order on a substrate, and by using a hole transporting material such as TPD for the charge transporting protection layer.

Electroluminescence element

A main object of the present invention is to provide an organic EL element being excellent in light emitting characteristics, characteristics of an organic EL layer and current-voltage characteristic. To attain the object, the invention discloses&#x2014;an organic electroluminescent element comprises a substrate, an anode layer formed on the substrate, an organic electroluminescent layer formed on the anode layer and&#x2014;containing at least a light emitting layer, a semitransparent cathode layer formed on the organic electroluminescent layer, a transparent buffer layer formed on the semitransparent cathode layer and having an impact buffering function, and a transparent electroconductive protection layer formed on the transparent buffer layer and having an oxidation preventing function. A contact region in which the semitransparent cathode layer and the transparent electroconductive protection layer contact with each other is provided in a non-display area.

Growing community of inventors

Tokyo, Japan

Tomonori Akai