Eisai R&d Management Co., Ltd.

Mercian Corporation

Eisai Company, Limited

Tomonari Yamada

Susumu Takeda

Kiyoshi Okamoto

Mitsuo Nagai

Yoshihiko Kotake

Jun Niijima

Takashi Nakashima

Satoshi Yamamoto

Toshio Tsuchida

Kazuyuki Dobashi

Masashi Yoshida

Yoshiharu Mizui

Toshimitsu Uenaka

Tomohiro Sameshima

Naoto Kawamura

Takao Yamori

Masanori Fujita

Naoki Asai

Motoko Matsufuji

Takashi Sakai

Akifumi Okuda

Kumiko Kishi

Masao Iwata

Koji Norihisa

Hiroshi Ishihara

Keisuke Komeda

Yoshiaki Asahi

The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution ofsp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it. 

Bioactive substance

The present invention provides a method for stabilizing a macrolide compound, and an efficient method for producing the compound. Specifically, it provides a method for stabilizing a macrolide compound, in which a 12-membered ring macrolide compound, such as a compound expressed by the formula (1) and a cyclodextrin are both present, and a method for producing a macrolide compound, in which a cyclodextrin is made to be present in a culture broth of actinomycetes having an ability of producing the macrolide compound.

Method for stabilizing macrolide compounds

The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution ofsp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it

Physiologically active substances

Growing community of inventors

Shizuoka, Japan

Tomonari Yamada