Kissei Pharmaceutical Co., Ltd.

Tomonaga Ozawa

Tetsuya Nakamura

Tetsuro Tamai

Hideyuki Muranaka

Takehiro Ishikawa

Satoshi Akahane

Junichi Kobayashi

Yuichiro Kai

Tatsuhiro Kondo

Ritsu Suzuki

Takashi Miyagi

Nobuhiko Fushimi

Kohsuke Ohno

Norihiko Kikuchi

Makio Kitazawa

Hiroaki Shiohara

The present invention provides a compound useful as an agent for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides a fused heterocyclic derivative represented by the following general formula (I), a pharmaceutical composition containing the same, a medicinal use thereof and the like. In the formula (I), ring A represents 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; Rrepresents halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like ; ring B represents aryl or heteroaryl; Rrepresents halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; Eand Erepresent an oxygen atom or the like; U represents a single bond or alkylene; X represents a group represented by Y, &#x2014;SO&#x2014;Y, &#x2014;O&#x2014;(alkylene)&#x2014;Y, &#x2014;O&#x2014;Z in which Y represents Z, amino or the like; Z represents cycloalkyl, heterocycloalkyl, aryl, heteroaryl or the like; or the like. 

Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof

The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein Rand Rare each hydrogen or lower alkyl; R, R, Rand Rare each hydrogen, halogen, lower alkyl or lower alkoxy; Rand Rare each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; Ris &#x2014;C(O)&#x2014;R, -A-C(O)&#x2014;R, &#x2014;O-A-C(O)&#x2014;Ror a tetrazol-5-yl group, which exhibit potent and selective &#x3b2;3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof

The present invention provides a compound represented by general formula (I): or pharmaceutically acceptable salts thereof, wherein W is O, S(O), CHand the like; Ris halogen, lower alkyl, halo-lower alkyl, CN and the like; Ris hydrogen and the like; Ris hydrogen, halogen, alkyl, halo-lower alkyl, substituted alkyl, aryl, aralkyl, alkoxy, substituted alkoxy, alkanoyl, aroyl, &#x2014;CONR(R), &#x2014;S(O)R, &#x2014;SONR(R) and the like; Ris hydrogen, halogen, alkyl, substituted alkyl and the like; A is &#x2014;N(R)CO&#x2014;A&#x2014;CORand the like; pharmaceutical compositions containing them and their uses, which have a high affinity to human thyroid hormone receptors, in particular human thyroid hormone receptor &#x3b2;.

Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof

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Matsumoto, Japan

Tomonaga Ozawa