Taisho Pharmaceutical Co., Ltd.

Sagami Chemical Research Center

Mercari, Inc.

Mercian Corporation

Tomomi Ota

Katsuo Hatayama

Kazuyuki Tomisawa

Yoshiaki Watanabe

Minoru Taguchi

Naoya Ono

Tetsuya Yabuuchi

Fumiyasu Shiozawa

Tetsuo Takayama

Toshihisa Ogawa

Hironori Katakai

Misa Nakanishi

Shuichi Sato

Takemi Sunaga

Takashi Adachi

Masakazu Sato

Takeo Yoshioka

Kaoru Sota

Takashi Nakashima

Kunio Isshiki

Kensei Yoshikawa

Makoto Yagi

Yutaka Ohuchi

Tatsuhiko Sano

Kazuto Sekiuchi

Kikuo Sugimoto

Hiroshi Tsunekawa

Takeshi Koami

Takeo Kobori

Shota Nagayama

Izumi Aibe

Rie Nishikawa

Kenichi Goda

A search device, a search method, and a search program for causing a quantum computer to search for angles of joints of a robot such as a robot arm at which the posture of the robot satisfies a predetermined condition by using a quantum algorithm are provided. The search device includes a specifying unit that specifies a function for identifying whether or not a posture of a robot satisfies a predetermined condition, a setting unit that applies a unitary transformation formed based on the function to a plurality of qubits corresponding to an angle of a joint of the robot a number of times according to the number of the plurality of qubits and sets a quantum computer so as to search for a state of the plurality of qubits corresponding to the angle satisfying the predetermined condition according to a quantum algorithm, and a calculation unit that calculates the angle corresponding to a measurement value of the plurality of qubits.

Search apparatus, search method, and search program

An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P), and is useful as a pharmaceutical compound. A compound or a pharmaceutically acceptable salt thereof, which compound is represented by the formula below (where A represents an oxygen atom, a sulfur atom, a group represented by Formula &#x2014;SO&#x2014;, a group represented by Formula &#x2014;SO&#x2014;, or the like, Rrepresents a hydrogen atom, an alkyl group having 1-6 carbon atoms, or the like, Rrepresents a hydrogen atom or the like, Rrepresents an alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-6 carbon atoms, or the like, Rrepresents an aryl group, Rrepresents a hydrogen atom or an alkyl group having 1-6 carbon atoms and optionally substituted with a carboxyl group, and Rrepresents an alkyl group having 1-10 carbon atoms, a cycloalkyl group having 3-8 carbon atoms, an aryl group which is optionally substituted, or the like).

Triazole derivative

The present invention aims to provide compounds which have an inhibitory effect on the binding between S1P and its receptor Edg-1(S1P) and which are useful for pharmaceutical purposes. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: [wherein Ar represents a monocyclic heterocyclic ring containing one or two nitrogen atoms, A represents an oxygen atom or the like, Y, Yand Yeach represent a carbon atom or a nitrogen atom, Rrepresents a hydrogen atom, a C-Calkyl group or the like, Rrepresents a C-Calkyl group, a C-Ccycloalkyl group or the like, Rrepresents a C-Calkyl group or the like, Rrepresents a hydrogen atom or a C-Calkyl group, and Rrepresents a C-Calkyl group or the like].

Binding inhibitor of sphingosine-1-phosphate

2-Phenoxyaniline derivatives

2-phenoxyaniline derivatives

Amino compounds and angiotensin IV receptor agonists

Optically active 1,4-dihydropyridine compounds and the microbial process

A 1,4-dihydropyridine derivative represented by the formula ##STR1## wherein X is a hydrogen atom or an alkoxy group having 1 to 4 carbon atoms, A and B are the same or different and are each an alkylene group having 1 to 4 carbon atoms, and a pharmaceutically acceptable salt thereof are useful as the preventive and therapeutical agents of ischemic heart disease and hypertension.

1,4-dihydropyridine derivatives

A 1,4-dihydropyridine derivative represented by the formula ##STR1## wherein R.sup.1 is a hydrogen atom, an alkoxy group having 1 to 4 carbon atoms, a mercapto group, an alkylcarbonylthio group in which the alkyl group has 1 to 4 carbon atoms or a benzoylthio group, R.sup.2 is a mercapto group, an alkylcarbonylthio group in which the alkyl group has 1 to 4 carbon atoms, a benzoylthio group or a 2-cyanoethylthio group, A and B are the same or different and are each an alkylene group having 1 to 4 carbon atoms, and X is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group is disclosed. These compounds increase the therapeutic effect of drug-resistant cancers.

Novel styrene derivatives of the general formula ##STR1## wherein X is hydrogen or halogen, X.sup.1 is halogen, R is hydrogen or methyl, Y is hydroxymethyl, carboxyl, --COOR.sup.1 or --COR.sup.2 wherein R.sup.1 is prenyl, geranyl, farnesyl, cyclohexyl, phthalidyl, straight or branched chain alkyl having 1 to 6 carbon atoms, or said alkyl substituted with hydroxy, methoxy, pyridyl or alkanoyloxy having 2 to 16 carbon atoms, and R.sup.2 is amino, hydroxyamino mono-(or di-)alkylamino in which the alkyl moiety contains 1 or 2 carbon atoms, ethoxycarbonylmethylamino, carboxymethylamino, thiazolylamino, cyclohexylamino, pyridylamino, morpholino, N-methylpiperazino, phenylamino, phenylamino substituted with one or two of halogen, hydroxy, methyl, methoxy, trifluoromethyl or carboxyl at the phenyl ring, and the pharmaceutically acceptable salts thereof when Y is carboxyl are disclosed. These compounds exhibit high and long-lasting anti-inflammatory, analgesic and anti-pyretic activity.

Novel styrene derivatives of the general formula

Growing community of inventors

Tokyo, Japan

Tomomi Ota