Chanel Parfums Beaute

Nof Corporation

Tomomi Kuromiya

Daisuke Suzuki

Masayoshi Miyamoto

Hisao Ito

Mitsuhiro Fukushima

Hideyuki Yamaki

Yuki Munekata

Chikako Ichikawa

Fumitaka Ishimori

Chikako Nagahiro

To provide an acrylic silicone graft copolymer capable of effectively exerting a function in a composition for external application containing various oily components such as a natural oil, a hydrocarbon oil, ester oil and a silicone oil, and a composition for external application containing the acrylic silicone graft copolymer. A composition for external application including an acrylic silicone graft copolymer, which contains 2 to 25 mass % of a constitutional unit represented by formula (I), 55 to 85 mass % of a constitutional unit represented by formula (II) and 2 to 20 mass % of a constitutional unit represented by formula (III). wherein R1 is an alkyl group having 1 to 4 carbon atoms; R2 is an alkylene group having 2 to 10 carbon atoms; and n is an integer of 1 to 100.

Composition for external application and method for producing the same

A composition for external use containing a tranexamate as an active ingredient with suppressed sticky or oily feeling but having a fresh feel of use, and a method for producing the same. A tranexamate salt can be dispersed stably in an aqueous medium by (a) dissolving the tranexamate salt and an amphiphilic polymer in water, a water-soluble organic solvent or a mixture thereof; and (b) adding a mixed solution obtained in the step (a) to an aqueous medium, and thus keeping the tranexamate salt in molecular assembly particles formed of the amphiphilic polymer.

Method for producing composition for external use containing physiologically acceptable salt of tranexamate

Disclosed is an oil-in-water type emulsion composition containing a physiologically acceptable salt of a tranexamate ester and a method for producing the same. An oil-in-water type emulsion composition containing a physiologically acceptable salt of a tranexamate ester can be obtained by preparing an oil phase including: A) a physiologically acceptable salt of a tranexamate ester; B) an amphiphilic substance; C) an oily substance; and D) water, a water-soluble organic solvent or a mixture thereof wherein the weight ratio of the ingredients A:B is in the range of 1:0.5 to 1:2.5, the weight ratio of the ingredients A:C is in the range of 1:1 to 1:5.0, and the weight ratio of the ingredients A:D is 1:0.2 to 1:5.0, and adding the oil phase to a water phase including E) water, a water-soluble organic solvent or a mixture thereof.

Oil-in-water emulsion composition and method for producing the same

A composition for external use containing a physiologically acceptable salt of a tranexamate as an active ingredient, which is dispersed in the composition in the state of fine particles, is provided. Thereby, a physiologically acceptable salt of the tranexamate is dissolved in a solvent to prepare a solution, to which a salting-out agent is added to precipitate the salt. Such salt is so dispersed in a composition for external use in the state of fine particles that the tranexamate salt can be mixed without using a large amount of an oil component to obtain a composition for external use affording excellent feel of use and stability.

Composition for external use and method for producing the same

A method for producing a composition for external use containing a physiologically acceptable salt of a tranexamate as an active ingredient, which is dispersed in the composition in the state of fine particles, includes dissolving a physiologically acceptable salt of the tranexamate in a solvent to prepare a solution, to which a salting-out agent is added to precipitate the salt. Such salt is so dispersed in a composition for external use in the state of fine particles, that the tranexamate salt can be mixed without using a large amount of an oil component to obtain a composition for external use affording excellent feel of use and stability.

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Matsusaka, Japan

Tomomi Kuromiya