Takeda Pharmaceutical Company Limited

Takeda Chemical Industries, Inc.

Tomomi Ikemoto

Naohiro Fukuda

Kiminori Tomimatsu

Toshiaki Nagata

Tatsuya Ito

Takeshi Yamasaki

Misayo Sera

Hideya Mizufune

Akira Haze

Atsuko Nishiguchi

Yasuhiro Sawai

Hirohiko Nishiyama

Yasushi Isogami

Hiroyuki Hatano

Yoshifumi Kitamoto

The present invention provides a production method for 5-Aryl-1H-Pyrolle-3-Carbontirile compounds: The productions method provides key intermediates useful for a method of preparing additional pyrrole compounds useful as a pharmaceutical product, particularly an acid secretion inhibitor, a productions method of an intermediate used for this method, a novel intermediate, and the like.

Process for producing 5-aryl-1H-pyrolle-3-carbonitrile compounds by dehalogenation

The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction. 

Process for producing pyrrole compound

5-aryl-1H-pyrrole-3-carbonitrile and a pharmaceutical product using the same

The present invention provides an industrially advantageous method of producing a pyridazinone compound. The present invention relates to the following method of producing a pyridazinone compound: Formula (II), (IIIa), (IV) or (IV&#x2033;), Formula (IIIb), (Vb) or (V&#x2033;b), Formula (VI), (I) or (I&#x2033;), wherein each symbol is as described in the specification. 

Production method of pyridazinone compounds

A process for the production of an aromatic azo compound having a 2,3-dihydrobenzofuran ring bearing a diazo group at the 5-position of the ring by conducting the diazo coupling of a 2,3-dihydrobenzofuran derivative represented by the general formula (II): [wherein Rand Rare each independently Calkyl; Ris optionally substituted aryl; and R, Rand Rare each independently hydrogen, Calkyl, halogeno, Calkoxy, or Calkylthio] with a benzenediazonium salt having an electron-withdrawing group at the p- and/or o-position in a mixed solvent composed of water and a polar organic solvent.

Azo compounds and process for production thereof

A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates therefor. The process, which is for producing a compound represented by the formula:{wherein Z represents an electron-attracting group; W represents optionally substituted ethylene or optionally substituted vinylene; Rrepresents hydrogen or an optionally substituted hydrocarbon group; and X represents a divalent group [provided that when W represents optionally substituted vinylene, then &#x2014;X&#x2014;CH-Z is not &#x2014;X&#x2014;X&#x2014;CH, -Z (wherein Xrepresents sulfur or optionally substituted nitrogen and Xrepresents optionally substituted ethylene)]} or a salt thereof, is characterized by subjecting a compound represented by the formula (II) or a salt thereof:(wherein the symbols have the same meanings as the above) to a ring closure reaction in a solvent containing a carbonic diester.

Process for producing cyclic compound

A method including resolution of a diastereomeric mixture represented by the formulawherein Rand Rare the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, only one of Rand Rcontains one asymmetric carbon, and Ris an optically active and optionally substituted hydrocarbon group or an optically active and optionally substituted heterocyclic group, or a salt thereof, to produce the diastereomer having a steric configuration of the asymmetric carbon for Ror Rof an R configuration or an S configuration, or a salt thereof.

Process for preparation of optically active sulfonamides and intermediates for their synthesis

A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates therefor. The process, which is for producing a compound represented by the formula:{wherein Z represents an electron-attracting group; W represents optionally substituted ethylene or optionally substituted vinylene; Rrepresents hydrogen or an optionally substituted hydrocarbon group; and X represents a divalent group [provided that when W represents optionally substituted vinylene, then &#x2014;X&#x2014;CH&#x2014;Z is not &#x2014;X&#x2014;X&#x2014;CH&#x2014;Z (wherein Xrepresents sulfur or optionally substituted nitrogen and Xrepresents optionally substituted ethylene)]} or a salt thereof, is characterized by subjecting a compound represented by the formula (II) or a salt thereof:(wherein the symbols have the same meanings as the above) to a ring closure reaction in a solvent containing a carbonic diester.

Method for producing 1-substituted-1,2,3-triazole derivative

Processes for the preparation of 2,3-dihydrothiepine derivatives

A method of producing 5'-nucleotide, which comprises maintaining a nucleoside suspension in an organic solvent at a temperature not lower than about 20.degree. C., and then subjecting the resultant suspension to a phosphorylatipon of the nucleoside(s). According to the present invention, 5'-nucleotide can be produced from a nucleoside at high purity and high yield in a shortened reaction time, and impurity removal in the nucleotide purification process is easily accomplished.

Growing community of inventors

Osaka, Japan

Tomomi Ikemoto