Other

Fuso Pharmaceutical Industries, Ltd.

Kyushu University

Yamada, Ken-ichi

Tomomi Ide

Keiichi Yamamoto

Ken-ichi Yamada

Kenji Sunagawa

Saki Shinto

Go Ichien

Yuma Ishida

Ken-Ichi Yamada

The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions.

Therapeutic drug for lipid-peroxidation-induced diseases and screening method for therapeutic drugs for lipid-peroxidation-induced diseases

A detection reagent for comprehensively detecting an oxidized state and a glycated state of a low-density lipoprotein. While an oxidized low-density lipoprotein and a glycated low-density lipoprotein are detected with a fluolophore-labelled antibody, a lipid radical is detected with a fluorescent nitroxide 2,2,6-trimethyl-4-(4-nitrobenzo[1,2,5]oxadiazol-7-ylamino)-6-pentylpiperadine-1-oxyl (NBD-Pen).

Detection reagents and kit for identifying oxidized state and glycated state of low-density lipoproteins

The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions. 

An electrical stimulation device and method are provided for treating cardiovascular disease in a human or an animal, the device including at least one electrode configured for placement on a nerve site inside the human or the animal, the at least one electrode having a spherical shape, and an electrical stimulation application unit coupled to the at least one electrode and configured to apply electrical stimulation to a vagus nerve in a neck region of the human or the animal by the at least one electrode.

Stimulation device and method for treating cardiovascular disease

A stimulation device and method for treating cardiovascular disease in a human or an animal is provided, the method including placing a magnetic pulse application unit including a coil on a skin surface of a region of the human or the animal, and generating magnetic pulses around the coil, wherein the magnetic pulses induce currents in tissues in the region to stimulate a vagus nerve. The region may be a neck region or a chest region.

Growing community of inventors

Fukuoka, Japan

Tomomi Ide