Vertex Pharmaceuticals, Inc.

Msd K.k.

Tomoko Sunami

Michael P Mortimore

Mitsuru Ohkubo

Hayley Marie Binch

Nobuhiko Kawanishi

Masaya Hashimoto

Toshiharu Iwama

Michael Mortimore

The present invention relates to a compound of Formula (I): wherein Ris H or Calkyl; Ris H or Calkyl; Rand Rare each independently H or Calkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R; Ris H, hydroxy, Calkyl, or OCH; and Ris F or Cl, or a pharmaceutically acceptable salt or ester thereof.

Aminopyridine derivatives having Aurora A selective inhibitory action

The present invention relates to a compound of Formula (I): wherein: Ris H, &#x2014;NHCOOR, Ccycloalkyl, or phenyl; where the cycloalkyl and phenyl each independently may be substituted with one to three of the same or different substituents selected from R; Ris Calkyl which may be substituted with one to three of the same or different substituents selected from F and Cl; Ris H, &#x2014;COOH, &#x2014;CHCOOH, &#x2014;COOR, or &#x2014;CHCOOR; Ris Calkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from halogen atoms; Ris H, Calkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R; Ris F, Cl, CF, or Calkyl; Ris halogen atom, hydroxy, or cyano; W is selected from: Wis H, halogen atom, cyano, Calkyl, or Ccycloalkyl, or a pharmaceutically acceptable salt or ester thereof. 

Aminopyridine derivatives having aurora a selective inhibitory action

The present invention relates to a compound of Formula (I): 

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Tokai-mura, Japan

Tomoko Sunami