Shiseido Company, Limited

Nissan Motor Company Limited

Tomoko Saito

Kiyoshi Sato

Takako Shibata

Kimihiro Ogino

Naoto Hanyu

Yasutoshi Seko

Naota Hanyu

The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein X, X, and Xare each CRor N; R, R, and Rare each H, Calkyl, Calkoxy, SH, OH, or NRR, wherein Rand Rare each H, Calkyl, or hydroxy-Calkyl, or NRRforms a saturated or unsaturated 5- or 6-membered hetero ring; and B is a substituted or unsubstituted pyrazole, imidazole, pyridine, or piperidine; with the proviso that at least one of R, R, R, and Ris a group other than Calkyl in the case where X&#x2550;X&#x2550;Y&#x2550;N and X&#x2550;CR.

Whitening agent and skin external preparation

The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein, R, R, R, and Rare each independently Calkyl; and Rand Rare each independently a hydrogen atom or Calkyl.

Method for inhibiting melanin production and whitening skin with pyrimidlypyrazole compounds or pharmaceutically acceptable salts thereof

Method for inhibiting melanin production and whitening skin with pyrimidylpyrazole compounds or pharmaceutically acceptable salts thereof

The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a heterocyclic compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein R, R, and R' are each independently Calkyl; Y is S or O; and p is an integer of 0 to 3, wherein when p is 2 or 3, Rmay be the same or different.

Method for skin whitening

Disclosed herein is a vehicle headlamp which comprises an ellipsoidal light reflector having first and second focuses; a light source positioned at the first focus, so that light rays produced by the light source are reflected forward by the light reflector and converged at the second focus; a converging lens positioned in front of the second focus; a shading device positioned near the second focus for partially shading the light rays which have been reflected by the light reflector; and control means for controlling the shading characteristic of the shading device in accordance with an operation mode of the vehicle, wherein said shading device comprises a liquid crystal matrix which has a plurality of small light transmitting elements independently and electrically controlled by said control means.

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Yokohama, Japan

Tomoko Saito