Santen Pharmaceutical Co., Ltd.

Tomoko Oda

Kenji Kawashima

Masatomo Kato

Daisuke Shii

Hideki Miyake

Minoru Yamamoto

Toshiyuki Mori

Mamoru Matsuda

Miwa Takai

Masato Nagatsuka

Sachiko Kobayashi

Yusuke Yamazaki

Takahiro Matsuyama

Shinji Takaoka

Kazutaka Kido

Kensuke Nozaki

The present disclosure provides an agent for treating or preventing eye diseases such as presbyopia, comprising, as an active ingredient, 4-phenylbutyric acid or an ester thereof, or a pharmaceutically acceptable salt thereof.

Agent containing 4-phenylbutyrate, for preventing or treating presbyopia

A method for suppressing obstruction of meibomian gland in a mammalian subject, the method comprising administering to the mammalian subject an eye drop comprising 0.01 to 0.5% (w/v) of sirolimus or a pharmaceutically acceptable salt thereof as a sole active ingredient, wherein the eye drop is administered to an eye of the mammalian subject 1 to 2 times per day.

Therapeutic agent for meibomian dysfunction

The present disclosure provides an agent for treating or preventing eye diseases such as presbyopia, comprising, as an active ingredient, ursodeoxycholic acid or an amide conjugate of ursodeoxycholic acid, or an ester thereof, or a pharmaceutically acceptable salt thereof.

Ursodeoxycholic acid-containing agent for treating or preventing presbyopia

The present invention relates to defined quinoxalin-2-one compounds or a pharmaceutically acceptable salt or a hydrate or a solvate thereof. The compounds, salts or hydrates have a glucocorticoid receptor agonist activity, and are useful as a medicine, in particular as a prophylactic or therapeutic agent for a glucocorticoid receptor related disease.

[4-(1,3,3-trimethyl-2-OXO-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or salt thereof

The present invention relates to a novel [4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or a salt thereof. The compound or a salt thereof of the present invention has a glucocorticoid receptor agonist activity, and is useful as a medicine, in particular as a prophylactic or therapeutic agent for the glucocorticoid receptor related disease.

[4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or salt thereof

A method for changing a condition of an eyelid of a mammal excluding a human, a model animal for evaluating a therapeutic or prophylactic effect against an eyelid disease obtained by the method, a method for producing the model animal, a method of screening using the model animal and a substance having a therapeutic or prophylactic effect against an eyelid disease selected by the method of screening, and a therapeutic or prophylactic agent against an eyelid disease containing the substance as an active ingredient.

Method for changing condition of an eyelid for evaluation of an eyelid disease involving plugging of meibomian gland orifices and/or telangiectasia by administration of complete freund's adjuvant

A method of preventing or treating a glucocorticoid receptor-related disease involving administering a therapeutically effective amount of a 1,2-dihydroquinoline compound or a pharmaceutically acceptable salt thereof.

Method for preventing or treating a glucocorticoid receptor-related disease

An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; Rrepresents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; Rrepresents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; Rrepresents a hydrogen atom, an alkyl group, an alkenyl group or the like; Rand Rrepresent a hydrogen atom or the like; Rrepresents a hydrogen atom or the like; A represents an alkylene group or the like; and Rrepresents OR, NRR, SR, S(O)Ror S(O)R, wherein Rrepresents an aryl group, a heterocyclic group or the like and Rrepresents a hydrogen atom or the like. 

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Ikoma, Japan

Tomoko Oda