Kao Corporation

Tomoko Nomura

Koichi Ishida

Kimihiko Hori

Akira Sakaguchi

Keiko Suzuki

Junko Ishikawa

Mitsuru Sugiyama

Shuichi Tsuchiya

Yutaka Takagi

Takaaki Hori

Arisa Horiuchi

This invention relates to a food containing a glycosylated ceramide and diacylglycerol. This food is capable of improving and enhancing the barrier function of skin and increasing water holding capacity of the skin.

Food for skin moisture retention

An azole derivative represented by the following formula (I): ##STR1## wherein X is a nitrogen atom or CH, Y is an oxygen atom, a sulfur atom, an imino group, a methylimino group or a group represented by .dbd.N.about.O--, Z is one or two halogen atoms, n stands for a number of 1 or 2, the wavy line means that stereochemistry of the double bond is either E or Z; or an acid adduct thereof. They exhibit strong antifungal activities and are very useful in the therapy for fungus diseases. Also disclosed is an antifungal drug containing said compound as an active ingredient.

Azole derivatives and antifungal drugs containing the same as an active

An azole derivative represented by the following formula (I): ##STR1## wherein X is a nitrogen atom or CH, Y is an oxygen atom, a sulfur atom, an imino group, a methylimino group or a group represented by .dbd.N O--, Z is one or two halogen atoms, in stands for a number of 1 to 2, the wavy line means that stereochemistry of the double bond is either E or Z; or an acid adduct thereof. They exhibit strong antifungal activities and are very useful in the therapy for fungus diseases. Also disclosed is an antifungal drug containing said compound as an active ingredient.

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Utsunomiya, Japan

Tomoko Nomura