Sagami Chemical Research Center

Tomoko Nakamura

Yu Nagase

Takao Aoyagi

A polyorganosiloxane having a quaternary salt at its one terminal, of the following formula (I): ##STR1## wherein A is ##STR2## X.sup.- is a counter anion in the quaternary salt; each of R.sup.1 to R.sup.5 which may be the same or different, is an alkyl group, a substituted alkyl group or a phenyl group; Y is a C.sub.1-6 linear or branched bivalent alkylene or oxyalkylene group; and n is an integer of at least 1, provided that when n is 2 or more, each of R.sup.4 and R.sup.5 may be the same or different, wherein each of R.sup.6 to R.sup.8 which may be the same or different, is an alkyl group, a substituted alkyl group or a phenyl group, or R.sup.6 to R.sup.8 together form a ring and/or an unsaturated bond; R is a C.sub.1-6 alkyl group or a phenyl group; m is an integer of from 0 to 3, provided that when m is 2 or 3, R may be the same of different; and each of R.sup.9 to R.sup.11 which may be the same or different, is a phenyl group, a benzyl group or a C.sub.1-6 alkyl group. Such polyorganosiloxane is useful for promoting percutaneous absorption of a drug.

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Ayase, Japan

Tomoko Nakamura