Api Corporation

Mitsubishi Chemical Corporation

T. Hasegawa Co., Ltd.

Mayekawa Mfg. Co., Ltd.

Nippon Kasei Chemical Company Limited

Tomoko Maeda

Masato Murai

Jun Takehara

Takashi Ohtani

Tsugihiko Hidaka

Hiroshi Kawabata

Hisatoshi Uehara

Akira Nakanishi

Masaki Nagahama

Kenichi Satake

Naoko Sumitani

Yasumasa Dekishima

Yasuyo Saito

Naoyuki Watanabe

Yasutaka Ohkubo

Naomi Tomita

Norio Miyazawa

Takeshi Nakamura

Koji Nakamura

Eiji Kato

Masanori Yamazaki

Takeshi Murakami

Shingo Namiki

Toshiki Monden

Ryoma Miyake

Michiaki Fuji

Youichi Matsumoto

Hiroyuki Hayashi

Yuuichi Hirami

Kyoko Endo

Takako Takahashi

Hiroki Shibata

Kiminori Kawakami

Ritsuko Yamauchi

Tomoko Sasaki

Yuki Takuma

Yoshie Takami

Tadaoki Narumiya

Yuuki Asuma

Yoshio Hagura

Kosuke Ito

Kazuki Fukumoto

An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.

Rosuvastatin calcium and process for producing intermediate thereof

A thermoplastic resin including a structural unit of formula (1): wherein Ato Aare each independently ═CH— or ═N—, and at least one of Ato Ais ═N—. Rto Rare each independently a hydrogen atom, an alkyl group, an aryl group, a heteroaryl group, or the like. At least two adjacent groups out of Rto Rare optionally bonded to each other to form a ring. Rand Rare each independently a direct bond or an optionally substituted alkylene group having 1 to 20 carbon atoms. X is an oxygen atom, a carbonyl group, or an optionally substituted amino group, and n is an integer of 1 to 5. A retardation film, a circularly polarizing plate containing the thermoplastic resin are disclosed.

Thermoplastic resin, optical film made therefrom, diol compound, diester compound

The present invention provides a polyhydric phenol compound which has an excellent alkali resistance and which does not cause a deterioration in color even when used as a resin raw material or a color developer. The polyhydric phenol compound includes: a bisphenol compound (A) represented by the following Formula (1) and a trisphenol compound (B) represented by the following Formula (2): [wherein Rrepresents a monovalent aliphatic hydrocarbon group having from 6 to 24 carbon atoms; each of R, R, R, Rand Rrepresents a monovalent hydrocarbon group having from 1 to 15 carbon atoms; and each of a, b, c, d and e represents an integer from 0 to 4];

Polyhydric phenol compound and method of producing same

A method for producing (2S,5S)/(2R,5R)-5-hydroxypiperidine-2-carboxylic acid represented by the formula (10) below: the method including removing the protecting group from the hydroxyl group in a compound represented by formula (7) below: (wherein P represents a protecting group, Rrepresents an alkyl group containing 1 to 4 carbon atoms, and A represents an alkyl group containing 1 to 10 carbon atoms, an aryl group containing 6 to 12 carbon atoms, an alkyloxy group containing 1 to 4 carbon atoms, or an aralkyloxy group containing 7 to 20 carbon atoms)to synthesize a compound represented by formula (8) below: (wherein Rrepresents an alkyl group containing 1 to 4 carbon atoms, and A represents an alkyl group containing 1 to 10 carbon atoms, an aryl group containing 6 to 12 carbon atoms, an alkyloxy group containing 1 to 4 carbon atoms, or an aralkyloxy group containing 7 to 20 carbon atoms).

Method for producing 5-hydroxypiperidine-2-carboxylic acid

A method for producing (2S,5S)/(2R,5R)-5-hydroxypiperidine-2-carboxylic acid represented by the formula (10) below: the method comprising the step of removing the protecting group from the hydroxyl group in a compound represented by the formula (7) below: (wherein P represents a protecting group, Rrepresents an alkyl group containing 1 to 4 carbon atoms, and A represents an alkyl group containing 1 to 10 carbon atoms, an aryl group containing 6 to 12 carbon atoms, an alkyloxy group containing 1 to 4 carbon atoms, or an aralkyloxy group containing 7 to 20 carbon atoms) to synthesize a compound represented by the formula (8) below: (wherein Rrepresents an alkyl group containing 1 to 4 carbon atoms, and A represents an alkyl group containing 1 to 10 carbon atoms, an aryl group containing 6 to 12 carbon atoms, an alkyloxy group containing 1 to 4 carbon atoms, or an aralkyloxy group containing 7 to 20 carbon atoms).

The present invention relates to a polycarbonate resin containing, in the molecule, a structure represented by the following formula (1): wherein X has a structure represented by any one of the following formula (2) to (4): wherein each of Rto Rindependently represents a hydrogen atom or an organic group having a carbon number of 1 to 30; the organic group may have an arbitrary substituent, and any two or more members of Rto Rmay combine with each other to form a ring, which is excellent in heat resistance, transparency, light resistance, weather resistance and mechanical strength.

Polycarbonate resin

According to the present invention, it becomes possible to perform a process for converting into an &#x3b1;-substituted cysteine represented by general formula (1) or a salt thereof at low cost and on an industrial scale by employing a process that is routed through a compound represented by general formula (3) to a compound represented by general formula (6). Particularly, by employing a process that is routed through a compound represented by general formula (7-2), it becomes possible to detach a tert-butyl protection group in a simple manner and to produce the compound represented by general formula (1) with high purity. Furthermore, by employing a process that is routed through tert-butylthiomethanol or a process that is routed through a compound represented by general formula (9), it becomes possible to produce a compound represented by general formula (2) without generating bischloromethylether that is an oncogenic substance. In the production of an &#x3b1;-substituted-D-cysteine or a salt thereof, it becomes possible to perform a process for converting the compound represented by general formula (2) into a compound represented by general formula (3S) in one step by allowing an enzyme or the like to act on the compound represented by general formula (2).

Method for producing alpha-substituted cysteine or salt thereof or synthetic intermediate of alpha-substituted cysteine

A method for producing (2S,5S)/(2R,5R)-5-hydroxypiperidine-2-carboxylic acid represented by the formula (10) below: the method including removing the protecting group from the hydroxyl group in a compound represented by formula (7) below: (wherein P represents a protecting group, Rrepresents an alkyl group containing 1 to 4 carbon atoms, and A represents an alkyl group containing 1 to 10 carbon atoms, an aryl group containing 6 to 12 carbon atoms, an alkyloxy group containing 1 to 4 carbon atoms, or an aralkyloxy group containing 7 to 20 carbon atoms) to synthesize a compound represented by formula (8) below: (wherein Rrepresents an alkyl group containing 1 to 4 carbon atoms, and A represents an alkyl group containing 1 to 10 carbon atoms, an aryl group containing 6 to 12 carbon atoms, an alkyloxy group containing 1 to 4 carbon atoms, or an aralkyloxy group containing 7 to 20 carbon atoms).

The present invention aims to provide a method for purifying cis-5-hydroxy-2-piperidinecarboxylic acid with high purity, and a method for producing its derivative. The present invention provides a method for producing a cis-5-hydroxy-2-piperidinecarboxylic acid derivative, which method comprises a step of converting cis-5-hydroxy-2-piperidinecarboxylic acid into a compound(s) of Formula (1) and/or Formula (2) (wherein Rrepresents a protective group for an amino group, and R2 represents a C-Calkyl group), and a method for purifying cis-5-hydroxy-2-piperidinecarboxylic acid. 

Method for producing cis-5-hydroxy-2-piperidinecarboxylic acid derivative, and method for purifying cis-5-hydroxy-2-piperidinecarboxylic acid

A method for producing (2S,5S)/(2R,5R)-5-hydroxypiperidine-2-carboxylic acid represented by formula (10) below: the method including removing the protecting group from the hydroxyl group in a compound represented by formula (7) below: (wherein P represents a protecting group, Rrepresents an alkyl group containing 1 to 4 carbon atoms, and A represents an alkyl group containing 1 to 10 carbon atoms, an aryl group containing 6 to 12 carbon atoms, an alkyloxy group containing 1 to 4 carbon atoms, or an aralkyloxy group containing 7 to 20 carbon atoms)to synthesize a compound represented by formula (8) below: (wherein Rrepresents an alkyl group containing 1 to 4 carbon atoms, and A represents an alkyl group containing 1 to 10 carbon atoms, an aryl group containing 6 to 12 carbon atoms, an alkyloxy group containing 1 to 4 carbon atoms, or an aralkyloxy group containing 7 to 20 carbon atoms).

The present invention provides a polymerizable inorganic particle dispersant that can achieve an inorganic-organic composite particle and inorganic-organic resin composite material, which have a high refractive index and a high Abbe's number, i.e., which can achieve both of a high refractive index and a high Abbe's number that is non-conventional in a composite with an inorganic particle. The present invention relates to a polymerizable inorganic particle dispersant comprising a compound which includes the following functional groups A, B and Q: A: Polymerizable functional group; B: Carboxyl group, Oxo acid group containing a phosphorous or Oxo acid group containing sulfur; and C: Sulfur-containing divalent or more aliphatic hydrocarbon group, which may contain a hetero atom other than sulfur.

Polymerizable inorganic-particle dispersant, inorganic-organic composite particles containing said polymerizable inorganic-particle dispersant, and inorganic-organic resin composite material

This invention offers 6,8,10-undecatrien-3-ol and 6,8,10-undecatrien-4-ol. These compounds possess not only woody green note, but also fruity note rich in naturality and freshness, and aroma compositions blended therewith are useful for imparting fragrance and flavor to food and beverage, perfumed cosmetics, medicaments and the like.

6,8,10-undecatrien-3-ol or 6,8,10-undecatrien-4-ol, and aroma compositions

This invention offers 6,8,10-undecatrien-3-one or 6,8,10-undecatrien-4-one which are represented by the following formula (1) 

6,8,10-undecatrien-3-one or 6,8,10-undecatrien-4-one, and aroma compositions

A process for efficiently producing a nucleic acid derivative by condensing a specific nitrogen-containing heterocyclic compound such as a dinitrogen 6-membered heterocyclic compound or a trinitrogen 5-membered heterocyclic compound with a pentose using a less expensive and safe reagent. Namely, a process for producing a nucleic acid derivative by condensing a dinitrogen 6-membered heterocyclic compound or a trinitrogen 5-membered heterocyclic compound with a pentose in the presence of an iron halide.

Process for producing nucleic acid derivative

Growing community of inventors

Kanagawa, Japan

Tomoko Maeda