Taisho Pharmaceutical Co., Ltd.

Nissan Chemical Industries Limited

Tomoko Ishizaka

Takeshi Kuwada

Daisuke Wakasugi

Naoki Miyakoshi

Youichi Shimazaki

Nobutaka Hattori

Shin-ichi Shirokawa

Mitsukane Yoshinaga

Shin-Ichi Shirokawa

Takaaki Ishii

Toshio Nakamura

Toshihito Kumagai

Taketoshi Okubo

Yoshinori Sekiguchi

Takanori Shimizu

Kumi Abe

Xiang-Min Sun

Yuri Amada

Shigetada Sasako

Takayuki Nagatsuka

The present invention provides agents for treating or preventing diseases such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, alopecia, and so forth. Specifically, the invention provides azole derivatives represented by general formula (I), or pharmaceutically acceptable salts thereof that have an antagonistic action against the arginine-vasopressin (AVP) V1b receptor: 

Azole derivative

The present invention provides a 1,2,4-triazolone derivative represented by Formula (1A) having an antagonistic activity on the arginine-vasopressin 1b receptor or a pharmaceutically acceptable salt thereof and provides a pharmaceutical composition comprising the compound or the salt as an active ingredient, in particular, a therapeutic or preventive agent exhibiting favorable pharmacokinetics in a disease such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, or alopecia. 

1, 2, 4-triazolone derivative and use thereof as an antagonist on the arginine-vasopressin 1B receptor

Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MCreceptor antagonistic effect.

Aminopyrrolidine compound

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Toshima-ku, Japan

Tomoko Ishizaka