Genox Research, Inc.

Eisai Company, Limited

Japan As Represented by General Director of Agency of National Center for Child Health & Development

Tomoko Fujishima

Takeshi Nagasu

Kaoru Ogawa

Yuji Sugita

Ryoichi Hashida

Yukiho Imai

Keiko Matsui

Nei Yoshida

Gozoh Tsujimoto

Eiki Takahashi

Tadahiro Oshida

Masaya Obayashi

Shigemichi Gunji

Izumi Obayashi

The differential display method was used to search for a gene whose expression level in eosinophils collected from patients with atopic dermatitis differs in the exacerbation stage and in the remission stage. As a result, gene '2090-05' showing a significant increase in expression in eosinophils of patients in the remission stage was isolated. This gene is usable in testing for an allergic disease and screening for a candidate compound for a therapeutic agent therefor an allergic disease.

Method of testing for allergic diseases

T cells from multiple subjects who showed different cedar pollen specific IgE titers were prepared before and after cedar pollen dispersal, and differential display analysis was performed to screen for pollen antigen responsive genes. As a result, a novel gene was successfully isolated whose expression is significantly higher in subjects with high cedar pollen specific IgE titer. The inventors have found that it is possible to use this gene to test for an allergic disease and to screen for candidate compounds for therapeutic drugs for an allergic disease.

Pollen allergy-related gene 513

Growing community of inventors

Tokyo, Japan

Tomoko Fujishima